Biology of Blood and Marrow Transplantation

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Identification of CD137+ IFN-g- CD4+ Alloreactive T Cells Post Myeloablative Double Cord Blood Transplant: A Synergistic Role in the Graft Verus Graft.
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Presentation transcript:

Biology of Blood and Marrow Transplantation Marked In Vivo Expansion of Donor T Regulatory Cells Via Targeting of the IL-2/CD25 and TL1A/TNFRSF25 Pathways Elicits Gender Differences and Ameliorates Gvhd  Dietlinde Wolf, PhD, Henry Barreras, BS, Cameron S. Bader, BS, Shirin Razdan, BS, Casey O. Lightbourn, BS, Brent J. Pfeiffer, MD, Sharon Jill Elliot, PhD, Eckhard R. Podack, MD, PhD, Krishna V. Komanduri, MD, Robert B. Levy, PhD  Biology of Blood and Marrow Transplantation  Volume 22, Issue 3, (March 2016) DOI: 10.1016/j.bbmt.2015.11.956 Copyright © 2016 Terms and Conditions

Fig 1A Gender disparity post Treg Expansion with TL1A-lg + IL-2. B. Amelioration of GVHD using female and male Treg expanded donor cells. Biology of Blood and Marrow Transplantation 2016 22, DOI: (10.1016/j.bbmt.2015.11.956) Copyright © 2016 Terms and Conditions