Genetic Variants in WNT2B and BTRC Predict Melanoma Survival

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Genetic Variants in WNT2B and BTRC Predict Melanoma Survival Qiong Shi, Hongliang Liu, Peng Han, Chunying Li, Yanru Wang, Wenting Wu, Dakai Zhu, Christopher I. Amos, Shenying Fang, Jeffrey E. Lee, Jiali Han, Qingyi Wei Journal of Investigative Dermatology Volume 137, Issue 8, Pages 1749-1756 (August 2017) DOI: 10.1016/j.jid.2017.04.023 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Screening for SNPs in the Wnt pathway genes. (a) Research workflow. (b) Manhattan plot of associations between 19,830 SNPs and CMSS. There are 1,855 SNPs with P < 0.05. The blue horizontal line indicates P = 0.05. CMSS, CM-specific survival; GWAS, genome-wide association study; HWE, Hardy Weinberg equilibrium; MAF, minor allele frequency; MDACC, MD Anderson Cancer Center; SNP, single-nucleotide polymorphism. Journal of Investigative Dermatology 2017 137, 1749-1756DOI: (10.1016/j.jid.2017.04.023) Copyright © 2017 The Authors Terms and Conditions

Figure 2 Selected SNPs and survival prediction. (a, b) Kaplan-Meier curves of cutaneous melanoma-specific survival (CMSS) stratified by WNT2B rs1175649, assuming a dominant model in (a) the MDACC study and (b) the Harvard study. (c, d) Kaplan-Meier curves of CMSS stratified by BTRC rs61873997, assuming a dominant model in (c) the MDACC study and (d) the Harvard study. (e, f) Kaplan-Meier survival curves of the combined risk genotypes: dichotomized groups of the NUG in (e) the MDACC study and (f) the Harvard study. BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase; MDACC, MD Anderson Cancer Center; NUG, number of unfavorable genotypes; SNP, single-nucleotide polymorphism; WNT2B, Wnt family member 2B. Journal of Investigative Dermatology 2017 137, 1749-1756DOI: (10.1016/j.jid.2017.04.023) Copyright © 2017 The Authors Terms and Conditions

Figure 3 Associations between rs1175649 genotypes and WNT2B mRNA expression levels. The expression quantitative trait loci (eQTLs) analysis for WNT2B rs1175649 in 373 Europeans from the 1000 Genomes Project in (a) the additive model and (b) the dominant model. (c) The eQTLs analysis from the Genotype-Tissue Expression (GTEx) project for WNT2B rs1175649 in an additive genetic model. WNT2B, Wnt family member 2B. Journal of Investigative Dermatology 2017 137, 1749-1756DOI: (10.1016/j.jid.2017.04.023) Copyright © 2017 The Authors Terms and Conditions