Fine Mapping and Identification of BMI Loci in African Americans

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Fine Mapping and Identification of BMI Loci in African Americans Jian Gong, Fredrick Schumacher, Unhee Lim, Lucia A. Hindorff, Jeff Haessler, Steven Buyske, Christopher S. Carlson, Stephanie Rosse, Petra Bůžková, Myriam Fornage, Myron Gross, Nathan Pankratz, James S. Pankow, Pamela J. Schreiner, Richard Cooper, Georg Ehret, C. Charles Gu, Denise Houston, Marguerite R. Irvin, Rebecca Jackson, Lew Kuller, Brian Henderson, Iona Cheng, Lynne Wilkens, Mark Leppert, Cora E. Lewis, Rongling Li, Khanh-Dung H. Nguyen, Robert Goodloe, Eric Farber-Eger, Jonathan Boston, Holli H. Dilks, Marylyn D. Ritchie, Jay Fowke, Loreall Pooler, Misa Graff, Lindsay Fernandez-Rhodes, Barbara Cochrane, Eric Boerwinkle, Charles Kooperberg, Tara C. Matise, Loic Le Marchand, Dana C. Crawford, Christopher A. Haiman, Kari E. North, Ulrike Peters The American Journal of Human Genetics Volume 93, Issue 4, Pages 661-671 (October 2013) DOI: 10.1016/j.ajhg.2013.08.012 Copyright © 2013 The American Society of Human Genetics Terms and Conditions

Figure 1 Manhattan Plot for Metabochip-Wide Analysis of BMI in African Americans The –log10 of p values for each SNP on the Metabochip is plotted against physical chromosomal positions. Green dots represent the SNPs in 21 BMI-related loci that were previously identified in European populations and fine-mapped on the Metabochip. Blue line: p = 2.5 × 10−7; red line: p = 5 × 10−8. The American Journal of Human Genetics 2013 93, 661-671DOI: (10.1016/j.ajhg.2013.08.012) Copyright © 2013 The American Society of Human Genetics Terms and Conditions

Figure 2 Regional-Association Plot for the New BMI-Related Locus at 2p23.2/BRE The –log10 of p values (left y axis) is plotted against the SNP genomic position based on NCBI build 37 (x axis); the estimated recombination rate from the 1000 Genomes Project for African populations is on the right y axis and is plotted in blue. The most significant SNP is denoted with a purple diamond. SNPs are colored to reflect correlation with the most significant SNP. Gene annotations are from the UCSC Genome Browser. The American Journal of Human Genetics 2013 93, 661-671DOI: (10.1016/j.ajhg.2013.08.012) Copyright © 2013 The American Society of Human Genetics Terms and Conditions