Volume 9, Issue 6, Pages 1152-1154 (June 2002) Big G, Little G  Louis M Luttrell  Molecular Cell  Volume 9, Issue 6, Pages 1152-1154 (June 2002) DOI: 10.1016/S1097-2765(02)00551-8

Figure 1 Rho Activation by Heterotrimeric G Proteins Activation of heterotrimeric G proteins generates free Gαq/12/13 and Gβγ subunits, which mediate the membrane recruitment and activation of Csk. The Gβγ subunit effect involves the physical association of Gβγ and Csk, while the Gαq/12/13 effect is mediated through as yet unknown intermediates. Csk activates Rho either by relieving the Rho inhibition that is caused by Src-mediated activation of p190RhoGAP or by alternative mechanisms, possibly including activation of a RhoGEF. Molecular Cell 2002 9, 1152-1154DOI: (10.1016/S1097-2765(02)00551-8)