Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn’s Disease Kenji Watanabe, Takayuki Matsumoto,

Slides:

Advertisements

Similar presentations

A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells Toshiaki Teratani, Kengo Tomita,

Advertisements

Risk of Neoplasia After Colectomy in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis Lauranne A.A.P. Derikx, Loes H.C.

Post-treatment Levels of α-Fetoprotein Predict Incidence of Hepatocellular Carcinoma After Interferon Therapy Tsugiko Oze, Naoki Hiramatsu, Takayuki.

Opened Proton Pump Inhibitor Capsules Reduce Time to Healing Compared With Intact Capsules for Marginal Ulceration Following Roux-en-Y Gastric Bypass

L-carnitine Reduces Muscle Cramps in Patients With Cirrhosis

Ashwin N. Ananthakrishnan, Millie D. Long, Christopher F

Epidermoid Cyst in an Intrapancreatic Accessory Spleen Diagnosed by Typical Radiographic Images and Endoscopic Ultrasound Fine-Needle Aspiration Findings.

Saurabh Dawra, Vishal Sharma, Usha Dutta

Branched-Chain Amino Acids Prevent Hepatocarcinogenesis and Prolong Survival of Patients With Cirrhosis Takumi Kawaguchi, Koichi Shiraishi, Toshifumi.

Nitsan Maharshak, Scott E. Plevy

Volume 151, Issue 6, Pages (December 2016)

Endoscopic Papillary Balloon Dilation for Bile Duct Stone: Immediate and Long-Term Outcomes in 1000 Patients Takeshi Tsujino, Takao Kawabe, Yutaka Komatsu,

The Probiotic Preparation, VSL#3 Induces Remission in Patients With Mild-to- Moderately Active Ulcerative Colitis Ajit Sood, Vandana Midha, Govind K.

Pichamol Jirapinyo, Christopher C. Thompson

Efficacy of Endoscopic Mucosal Resection With Circumferential Incision for Patients With Large Colorectal Tumors Taku Sakamoto, Takahisa Matsuda, Takeshi.

Katsunori Matsueda, Tatsuya Toyokawa

A Shocking Cystory Clinical Gastroenterology and Hepatology

Small Bowel Injury by Low-Dose Enteric-Coated Aspirin and Treatment With Misoprostol: A Pilot Study Toshio Watanabe, Satoshi Sugimori, Natsuhiko Kameda,

Prevalence of Irritable Bowel Syndrome–type Symptoms in Patients With Celiac Disease: A Meta-analysis Anita Sainsbury, David S. Sanders, Alexander C.

Mucosal Healing in Patients With Celiac Disease and Outcomes of Pregnancy: A Nationwide Population-Based Study Benjamin Lebwohl, Olof Stephansson, Peter.

Stephen A. Harrison, MD, FACP Clinical Gastroenterology and Hepatology

Wireless Capsule Endoscopy Fragmentation in a Patient With Crohn's Disease Marcia Henriques de Magalhães Costa, Andre da Luz Moreira, Cyrla Zaltman Clinical.

Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn’s Disease Kenji Watanabe, Takayuki Matsumoto,

Volume 144, Issue 4, Pages (April 2013)

Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double- Blind, Placebo-Controlled Trial Hiroyuki Hanai, Takayuki Iida, Ken.

Volume 154, Issue 4, Pages (March 2018)

Pancreatic Duct Drainage for the Treatment of a Huge Pancreatic Cyst Associated With Autoimmune Pancreatitis Hiroyuki Matsubayashi, Toru Matsui, Hiroyuki.

Miguel Regueiro, Kevin E. Kip, Leonard Baidoo, Jason M

Activity-Based Costing and Management in a Hospital-Based GI Unit

Endoscopic Therapy for Barrett's Esophagus

AGA Clinical Practice Update on Functional Gastrointestinal Symptoms in Patients With Inflammatory Bowel Disease: Expert Review Jean-Frederic Colombel,

Ability of Rabeprazole to Prevent Gastric Mucosal Damage From Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype Takahiro Uotani, Mitsushige.

Leon P. McLean, Jonathan S. Chun, Raymond K. Cross

Volume 149, Issue 7, Pages e2 (December 2015)

Miho Sakumura, Kazuto Tajiri, Toshiro Sugiyama

Thurarshen Jeyalingam, Yuto Shimamura, Christopher Teshima

Optimizing Anti-TNF-α Therapy: Serum Levels of Infliximab and Adalimumab Are Associated With Mucosal Healing in Patients With Inflammatory Bowel Diseases

Endoscopic Ultrasound–Guided Cholecystoduodenostomy for Acute Cholecystitis in a Patient With Thrombocytopenia and End-Stage Liver Disease Awaiting Transplantation

Cannabis Induces a Clinical Response in Patients With Crohn's Disease: A Prospective Placebo-Controlled Study Timna Naftali, Lihi Bar-Lev Schleider,

Endoscopic Ultrasound–Guided Fine-Needle Aspiration of Ascites

David H. Bruining, William J. Sandborn

Najat Mourra, Nikias Colignon Clinical Gastroenterology and Hepatology

Clinical Features, Response to Treatment, and Outcomes of IgG4-Related Sclerosing Cholangitis Atsushi Tanaka, Susumu Tazuma, Kazuichi Okazaki, Takahiro.

Peter Bytzer Clinical Gastroenterology and Hepatology

Adalimumab for the Treatment of Japanese Patients With Intestinal Behçet’s Disease Satoshi Tanida, Nagamu Inoue, Kiyonori Kobayashi, Makoto Naganuma,

Mucosal Healing Is Associated With Improved Long-term Outcomes of Patients With Ulcerative Colitis: A Systematic Review and Meta-analysis Shailja C.

Patient-Reported Outcomes and Endoscopic Appearance of Ulcerative Colitis: A Systematic Review and Meta-analysis Neeraj Narula, Abdul-Aziz Alshahrani,

Association Between Pharmacokinetics of Adalimumab and Mucosal Healing in Patients With Inflammatory Bowel Diseases Xavier Roblin, Hubert Marotte, Melanie.

Effects of Different Coping Strategies on Physical and Mental Health of Patients With Irritable Bowel Syndrome Lilian Dindo, PhD Clinical Gastroenterology.

Issue Highlights Clinical Gastroenterology and Hepatology

L-carnitine Reduces Muscle Cramps in Patients With Cirrhosis

Endoscopic Ultrasound and Endoscopic Mucosal Resection Features of a Non–Protein Losing Form of Ménétrier's Disease Ferga C. Gleeson, Thomas F. Mangan,

Early Precut Sphincterotomy Does Not Increase Risk During Endoscopic Retrograde Cholangiopancreatography in Patients With Difficult Biliary Access: A.

Nicolas Williet, William J. Sandborn, Laurent Peyrin–Biroulet

Probiotics Prevent Hepatic Encephalopathy in Patients With Cirrhosis: A Randomized Controlled Trial Manish Kumar Lunia, Barjesh Chander Sharma, Praveen.

Christopher Hung, Desmond Leddin

Coagulation in Liver Disease: A Guide for the Clinician

Issue Highlights Clinical Gastroenterology and Hepatology

Endoscopic Assessment and Treating to Target Increase the Likelihood of Mucosal Healing in Patients With Crohn’s Disease Guillaume Bouguen, Barrett G.

Issue Highlights Clinical Gastroenterology and Hepatology

Endoscopic Therapy of Jejunal Diphyllobothrium nihonkaiense Infection

Masaya Iwamuro, Koichiro Tsutsumi, Hiroyuki Okada

Coloduodenal Fistula in Crohn’s Disease

Rintaro Hashimoto, Akimichi Chonan

Adverse Outcomes: Why Bad Things Happen to Good People

Masashi Miyazaki, Shotaro Nakamura, Takayuki Matsumoto

Medical Therapy for Refractory Pediatric Crohn’s Disease

Gastric Metastases From Anaplastic Pancreatic Cancer

Rintaro Hashimoto, Akimichi Chonan

Combination Therapy With Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy: A Post Hoc Analysis Jean-Frédéric Colombel,

Presentation transcript:

Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn’s Disease Kenji Watanabe, Takayuki Matsumoto, Tadakazu Hisamatsu, Hiroshi Nakase, Satoshi Motoya, Naoki Yoshimura, Tetsuya Ishida, Shingo Kato, Tomoo Nakagawa, Motohiro Esaki, Masakazu Nagahori, Toshiyuki Matsui, Yuji Naito, Takanori Kanai, Yasuo Suzuki, Masanori Nojima, Mamoru Watanabe, Toshifumi Hibi Akira Andoh, Toshifumi Ashida, Katsuya Endo, Yutaka Endo, Motohiro Esaki, Hiroshi Fujita, Mikihiro Fujiya, Ken Haruma, Toshifumi Hibi, Sakiko Hiraoka, Ichiro Hirata, Tadakazu Hisamatsu, Yutaka Honda, Hideki Iijima, Bunei Iizuka, Kentaro Ikeya, Takuya Inoue, Syuji Inoue, Tetsuya Ishida, Yo Ishiguro, Shyunji Ishihara, Hiroaki Ito, Ryuichi Iwakiri, Takashi Kagaya, Takanori Kanai, Hiroshi Kashida, Shingo Kato, Jun Kato, Takehiko Katsurada, Fukunori Kinjyo, Kiyonori Kobayashi, Mayumi Kodama, Reiko Kunisaki, Koichi Kurahara, Takafumi Kurokami, Lee Kyouwon, Koichiro Matsuda, Kazuhiro Matsueda, Toshiyuki Matsui, Takayuki Matsumoto, Keiichi Mitsuyama, Yuji Mizokami, Satoshi Motoya, Yuji Naito, Tomoo Nakagawa, Shiro Nakamura, Hiroshi Nakase, Masanori Nojima, Masafumi Nomura, Atsuhiro Ogawa, Kazuichi Okazaki, Kazuaki Otsuka, Hirotake Sakuraba, Masayuki Saruta, Makoto Sasaki, Takayuki Shirai, Tomoaki Suga, Kazuhito Sugimura, Toshiro Sugiyama, Yasuo Suzuki, Fuminao Takeshima, Hiroyuki Tamaki, Shinji Tanaka, Satoshi Tanida, Keiichi Tominaga, Taku Tomizawa, Kenji Watababe, Mamoru Watanabe, Kenji Watanabe, Syojiro Yamamoto, Masaki Yamashita, Atsushi Yoshida, Naoki Yoshimura Kenji Watanabe, Takayuki Matsumoto, Tadakazu Hisamatsu, Hiroshi Nakase, Satoshi Motoya, Naoki Yoshimura, Tetsuya Ishida, Shingo Kato, Tomoo Nakagawa, Motohiro Esaki, Masakazu Nagahori, Toshiyuki Matsui, Yuji Naito, Takanori Kanai, Yasuo Suzuki, Masanori Nojima, Mamoru Watanabe, Toshifumi Hibi Akira Andoh, Toshifumi Ashida, Katsuya Endo, Yutaka Endo, Motohiro Esaki, Hiroshi Fujita, Mikihiro Fujiya, Ken Haruma, Toshifumi Hibi, Sakiko Hiraoka, Ichiro Hirata, Tadakazu Hisamatsu, Yutaka Honda, Hideki Iijima, Bunei Iizuka, Kentaro Ikeya, Takuya Inoue, Syuji Inoue, Tetsuya Ishida, Yo Ishiguro, Shyunji Ishihara, Hiroaki Ito, Ryuichi Iwakiri, Takashi Kagaya, Takanori Kanai, Hiroshi Kashida, Shingo Kato, Jun Kato, Takehiko Katsurada, Fukunori Kinjyo, Kiyonori Kobayashi, Mayumi Kodama, Reiko Kunisaki, Koichi Kurahara, Takafumi Kurokami, Lee Kyouwon, Koichiro Matsuda, Kazuhiro Matsueda, Toshiyuki Matsui, Takayuki Matsumoto, Keiichi Mitsuyama, Yuji Mizokami, Satoshi Motoya, Yuji Naito, Tomoo Nakagawa, Shiro Nakamura, Hiroshi Nakase, Masanori Nojima, Masafumi Nomura, Atsuhiro Ogawa, Kazuichi Okazaki, Kazuaki Otsuka, Hirotake Sakuraba, Masayuki Saruta, Makoto Sasaki, Takayuki Shirai, Tomoaki Suga, Kazuhito Sugimura, Toshiro Sugiyama, Yasuo Suzuki, Fuminao Takeshima, Hiroyuki Tamaki, Shinji Tanaka, Satoshi Tanida, Keiichi Tominaga, Taku Tomizawa, Kenji Watababe, Mamoru Watanabe, Kenji Watanabe, Syojiro Yamamoto, Masaki Yamashita, Atsushi Yoshida, Naoki Yoshimura Clinical Gastroenterology and Hepatology Volume 16, Issue 4, Pages 542-549.e1 (April 2018) DOI: 10.1016/j.cgh.2017.10.036 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 Flow chart. Flow chart of the endoscopic subanalysis of the DIAMOND trial. pts, patients. Clinical Gastroenterology and Hepatology 2018 16, 542-549.e1DOI: (10.1016/j.cgh.2017.10.036) Copyright © 2018 AGA Institute Terms and Conditions

Figure 2 Rates of endoscopic response and mucosal healing. Rates of endoscopic response (A) and mucosal healing (B) in the monotherapy group and combination group. Combo, combination therapy group; Mono, monotherapy group. Clinical Gastroenterology and Hepatology 2018 16, 542-549.e1DOI: (10.1016/j.cgh.2017.10.036) Copyright © 2018 AGA Institute Terms and Conditions

Figure 3 Impact of adalimumab trough level. The impact of adalimumab trough level at Week 26 on endoscopic response at Week 26 (A) or Week 52 (B). Clinical Gastroenterology and Hepatology 2018 16, 542-549.e1DOI: (10.1016/j.cgh.2017.10.036) Copyright © 2018 AGA Institute Terms and Conditions

Figure 4 Correlation between quartile of adalimumab trough level and achievement rate. The correlation between quartile of adalimumab trough level at Week 26 and achievement rate of endoscopic response or mucosal healing at Weeks 26 or 52. Clinical Gastroenterology and Hepatology 2018 16, 542-549.e1DOI: (10.1016/j.cgh.2017.10.036) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 1 Forest plot. Forest plot of the comparison between the monotherapy and combination therapy groups for endoscopic response and mucosal healing. Clinical Gastroenterology and Hepatology 2018 16, 542-549.e1DOI: (10.1016/j.cgh.2017.10.036) Copyright © 2018 AGA Institute Terms and Conditions