Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior

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Presentation transcript:

Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior Ramon J. Whitson, Anthony E. Oro Cell Stem Cell Volume 20, Issue 2, Pages 149-150 (February 2017) DOI: 10.1016/j.stem.2017.01.007 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Local Niches and Niche Factors Prime the Epigenetic Landscape of Normal and Cancer Stem Cells to Respond to Morphogens and Oncogenic Insults The same embryonic stem cell responds differently to diverse combinations of morphogens (BMP/FGF/Wnt), while application of local factors can alter the phenotypic outcome in disparate cell types, even with the same factor combination. Keratinocyte-derived tumors from the hair follicle, but not interfollicular epidermal, niche respond to one oncogenic insult (HRasG12D), but not another (loss of Ptch), by undergoing epithelial-to-mesenchymal transition (EMT). These data suggest that the pre-tumor epigenome plays an important prognostic role in predicting the behavior of human cancers. Cell Stem Cell 2017 20, 149-150DOI: (10.1016/j.stem.2017.01.007) Copyright © 2017 Elsevier Inc. Terms and Conditions