Clinical Applications for Change-Point Analysis of Herpes Zoster Pain

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Presentation transcript:

Clinical Applications for Change-Point Analysis of Herpes Zoster Pain Renee A. Desmond, PhD, Heidi L. Weiss, PhD, Ramin B. Arani, PhD, Seng-jaw Soong, PhD, Martin J. Wood, MD, Paul A. Fiddian, MD, John W. Gnann, MD, Richard J. Whitley, MD Journal of Pain and Symptom Management Volume 23, Issue 6, Pages 510-516 (June 2002) DOI: 10.1016/S0885-3924(02)00393-7

Fig. 1 Kaplan–Meier curves of the time to cessation of pain in patients with herpes zoster treated with oral valiciclovir or oral acyclovir , VACV-7, valiciclovir at 1000 mg for 7 days; VACV-14, valiciclovir at 1000 mg three times daily for 14 days; ACV-7, acyclovir at 800 mg five times daily for 7 days. Journal of Pain and Symptom Management 2002 23, 510-516DOI: (10.1016/S0885-3924(02)00393-7)

Fig. 2 Log of the Kaplan–Meier curves of time to cessation of pain for the VACV vs. ACV trial. Journal of Pain and Symptom Management 2002 23, 510-516DOI: (10.1016/S0885-3924(02)00393-7)

Fig. 3 Log of Kaplan–Meier curves of the time to cessation of pain in patients with herpes zoster treated in the open VACV study stratified by age group (≥50 years vs. <50 years). Journal of Pain and Symptom Management 2002 23, 510-516DOI: (10.1016/S0885-3924(02)00393-7)

Fig. 4 Phase-specific pain resolution rate per day (λ) for patients in the open VACV study of herpes zoster by age at presentation and phase using standard cutpoints (0, 30, 120). Journal of Pain and Symptom Management 2002 23, 510-516DOI: (10.1016/S0885-3924(02)00393-7)

Fig. 5 Phase-specific pain resolution rate per day (λ) for patients in the open VACV study of herpes zoster by age at presentation and baseline pain using standard cutpoints (0, 30, 120). Journal of Pain and Symptom Management 2002 23, 510-516DOI: (10.1016/S0885-3924(02)00393-7)