CpG Oligonucleotides Elicit Antitumor Responses in a Human Melanoma NOD/SCID Xenotransplantation Model Clemens Krepler, Volker Wacheck, Sabine Strommer,

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CpG Oligonucleotides Elicit Antitumor Responses in a Human Melanoma NOD/SCID Xenotransplantation Model Clemens Krepler, Volker Wacheck, Sabine Strommer, Gunther Hartmann, Peter Polterauer, Klaus Wolff, Hubert Pehamberger, Burkhard Jansen Journal of Investigative Dermatology Volume 122, Issue 2, Pages 387-391 (February 2004) DOI: 10.1046/j.0022-202X.2004.22202.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Growth of human melanoma xenotransplants in NOD/SCID mice. Therapy with CpG ODN or saline solution was started on day 5 after tumor inoculation, with subcutaneous injections three times a week until day 33. Mean±SD, n=6. Journal of Investigative Dermatology 2004 122, 387-391DOI: (10.1046/j.0022-202X.2004.22202.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Immunohistology of draining lymph nodes. (a), (b) stained with CD205 (DEC-205, Ly-75) for DC (a) of CpG-ODN-treated animals and (b) of saline-treated animals; (c), (d) stained using mLangerin antibodies for Langerhans-cell-derived DC (c) of CpG-ODN-treated animals and (d) of saline-treated animals. Scale bars: 50 μm. Journal of Investigative Dermatology 2004 122, 387-391DOI: (10.1046/j.0022-202X.2004.22202.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Peripheral blood serum levels of IL-12. (a) after 1 wk of treatment, mean±SD, n=3; (b) after 4 wk of treatment, pooled samples, n=6. Journal of Investigative Dermatology 2004 122, 387-391DOI: (10.1046/j.0022-202X.2004.22202.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Microphage infiltration in tumors. Tumor tissue after 1 wk of treatment, stained with F480 antibody for macrophages: (a) saline treated (b) CpG ODN treated. Scale bar: 50 μm. Journal of Investigative Dermatology 2004 122, 387-391DOI: (10.1046/j.0022-202X.2004.22202.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions