Relationship between knee pain and the presence, location, size and phenotype of femorotibial denuded areas of subchondral bone as visualized by MRI

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Relationship between knee pain and the presence, location, size and phenotype of femorotibial denuded areas of subchondral bone as visualized by MRI S. Cotofana, B.T. Wyman, O. Benichou, D. Dreher, M. Nevitt, J. Gardiner, W. Wirth, W. Hitzl, C.K. Kwoh, F. Eckstein, R.B. Frobell Osteoarthritis and Cartilage Volume 21, Issue 9, Pages 1214-1222 (September 2013) DOI: 10.1016/j.joca.2013.04.001 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Different phenotypes of the dABs as visualized quantitatively by MRI cartilage morphometry. (A & B) cartilage-loss-type dAB in the central medial femur (cMF) and medial tibia (MT) with (A) and without (B) segmentation. (C & D) intra-chondral-osteophyte-type dAB in the lateral tibia (LT) with (C) and without (D) segmentation. Osteoarthritis and Cartilage 2013 21, 1214-1222DOI: (10.1016/j.joca.2013.04.001) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Adjusted (age, sex, BMI) PR and the 95% CI for: ● = “weightbearing” knee pain; ○ = “non-weightbearing” knee pain; ▲ = ”frequent” knee pain; ▵ = “infrequent” knee pain and = “moderate-to-severe” knee pain in subjects with at least one femorotibial dAB (n = 245), peripheral dABs (n = 120), central dABs (n = 125), mildly denuded central subregions (≤10% of the subchondral bone area, n = 63) and moderately denuded central subregions (>10% of the subchondral bone area, n = 62). Bars display the upper and lower 95% CIs. Reference category (set as 1) is those without femorotibial dABs (n = 388). Osteoarthritis and Cartilage 2013 21, 1214-1222DOI: (10.1016/j.joca.2013.04.001) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 The femorotibial regions and subregion. (A) Showing the four femorotibial medial and lateral tibia (MT, LT) and (medial and lateral) central femur (cMF, cLF) and the 16 femorotibial subregions (10 tibial and six femoral): external, central, internal, anterior and posterior medial and lateral tibia (eMT, cMT, iMT, aMT, pMT and eLT, cLT, iLT, aLT, pLT) and external, central, internal central medial and lateral femur (ecMF, ccMF, icMF and ecLF, ccLF, icLF). The central subregions are highlighted in bold. (B) Showing an intra-chondral-osteophyte-type dAB in the central cMF. (C) Showing a cartilage-loss-type dAB in the central cMF (and MT). (D) Overview of the segmentation displayed in (B), showing the intra-chondral-osteophyte-type dAB in the central cMF comprising less than 10% of the central subregion. Additionally a small peripheral dAB can be seen in the posterior lateral tibia. (E) Overview of the segmentation displayed in (C), showing a cartilage-loss-type dAB affecting the central cMF and the external cMF but comprising more than 10% of the central subregion. Osteoarthritis and Cartilage 2013 21, 1214-1222DOI: (10.1016/j.joca.2013.04.001) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions