Figure MRI and histology of demyelinating lesion(A) Symmetric T2 hyperintensity in the midbrain with relative sparing of cerebral peduncles. MRI and histology.

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Presentation transcript:

Figure MRI and histology of demyelinating lesion(A) Symmetric T2 hyperintensity in the midbrain with relative sparing of cerebral peduncles. MRI and histology of demyelinating lesion(A) Symmetric T2 hyperintensity in the midbrain with relative sparing of cerebral peduncles. (B) Discrete T2-hyperintense lesion (biopsied subsequently) in the right temporal lobe. (C) T1 postcontrast image (arrow) showing enhancement of brainstem lesions. (D) The right temporal lesion is relatively sharply circumscribed and devoid of myelin (arrow), Luxol fast blue (myelin stain), 200×. (E) The lesion consists of large numbers of foamy macrophages (green arrow) and acute intraparenchymal hemorrhages (black arrow), hematoxylin and eosin stain, 400×. (F) Enlarging T2-hyperintense lesions in the midbrain and right temporal lobe immediately after biopsy. Shamik Bhattacharyya et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e90 © 2015 American Academy of Neurology