Pharmacogenetics of abacavir hypersensitivity: A systematic review and meta-analysis of the association with HLA-B*57:01 Bernardo Sousa-Pinto, BMed,

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Presentation transcript:

Pharmacogenetics of abacavir hypersensitivity: A systematic review and meta-analysis of the association with HLA-B*57:01 Bernardo Sousa-Pinto, BMed, João Pinto-Ramos, BMed, Cláudia Correia, BMed, Gustavo Gonçalves-Costa, BMed, Lídia Gomes, BMed, Sara Gil-Mata, BMed, Luís Araújo, MD, Luís Delgado, MD, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 4, Pages 1092-1094.e3 (October 2015) DOI: 10.1016/j.jaci.2015.03.019 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Association between HLA-B*57:01 expression and abacavir-induced hypersensitivity according to diagnostic criteria and ethnic group. Journal of Allergy and Clinical Immunology 2015 136, 1092-1094.e3DOI: (10.1016/j.jaci.2015.03.019) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 A, Summary of evidence search and selection. B, Funnel plot showing articles included in the meta-analysis according to criteria used to diagnose abacavir hypersensitivity (white, broad clinical criteria; gray, strict clinical criteria; black, patch testing). Journal of Allergy and Clinical Immunology 2015 136, 1092-1094.e3DOI: (10.1016/j.jaci.2015.03.019) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions