Susanne Wingert, Michael A. Rieger  Experimental Hematology 

Slides:



Advertisements
Similar presentations
Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle Isabel Beerman, Jun Seita, Matthew A.
Advertisements

Oxidative stress and hypoxia in normal and leukemic stem cells Ugo Testa, Catherine Labbaye, Germana Castelli, Elvira Pelosi Experimental Hematology Volume.
GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells Kenji Kitajima,
Fabian Mohr, Konstanze Döhner, Christian Buske, Vijay P.S. Rawat 
Stems Cells and the Pathways to Aging and Cancer
Susanne Wingert, Michael A. Rieger  Experimental Hematology 
Volume 15, Issue 1, Pages (July 2014)
Retinoblastoma Teaches a New Lesson
Martin Wahlestedt, David Bryder  Cell Stem Cell 
Ling Guo, Robert C.H. Zhao, Yaojiong Wu  Experimental Hematology 
Nishitha M. Reddy, Olalekan Oluwole, John P. Greer, Brian G
Cell Cycle Rules Pluripotency
Cassie J. Clarke, Tessa L. Holyoake  Experimental Hematology 
Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer
K. Lenhard Rudolph, Daniel Hartmann, Oliver G. Opitz  Gastroenterology 
Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies  Pankaj.
Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs
Vitamin C: C-ing a New Way to Fight Leukemia
Hematopoietic stem cell fate decisions are regulated by Wnt antagonists: Comparisons and current controversies  Corey J. Cain, Jennifer O. Manilay  Experimental.
Volume 11, Issue 3, Pages (September 2012)
Cellular Senescence in Cancer and Aging
Miki Ando, Hiromitsu Nakauchi  Experimental Hematology 
Ya-Huei Kuo, Jing Qi, Guerry J. Cook  Experimental Hematology 
Kaitlin A. Read, Michael D. Powell, Paul W. McDonald, Kenneth J
DNA-Damage Response in Tissue-Specific and Cancer Stem Cells
Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs
Kinetics and symmetry of divisions of hematopoietic stem cells
CBP/Catenin antagonists: Targeting LSCs’ Achilles heel
Getting blood from bone: An emerging understanding of the role that osteoblasts play in regulating hematopoietic stem cells within their niche  Yusuke.
Stem cell plasticity: Recapping the decade, mapping the future
Alison A. Laing, Christine J. Harrison, Brenda E. S
Location, Location, Location: The Cancer Stem Cell Niche
Quiescence regulators for hematopoietic stem cell
Qiuping He, Suwei Gao, Junhua Lv, Wei Li, Feng Liu 
Dietmar M.W. Zaiss, William C. Gause, Lisa C. Osborne, David Artis 
miR-34a and the Cardiomyopathy of Senescence: SALT PNUTS, SALT PNUTS!
Mira Jeong, Margaret A. Goodell  Experimental Hematology 
Christopher E. Schmitt, Carlos O. Lizama, Ann C. Zovein 
Arterial identity of hemogenic endothelium: a key to unlock definitive hematopoietic commitment in human pluripotent stem cell cultures  Igor I. Slukvin,
A New FOXO Pathway Required for Leukemogenesis
Jean Cadet, Thierry Douki  Journal of Investigative Dermatology 
Aspp1: A Guardian of Hematopoietic Stem Cell Integrity
Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer
847. Eradication of Therapy-Resistant Human Prostate Tumors Using an Ultrasound Guided Site-Specific Cancer Terminator Virus Delivery Approach    Molecular.
Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms  Janine Prick, Gerald de Haan, Anthony R. Green,
DNA Repair and Cytokine Responses
Blinded by the Light: The Growing Complexity of p53
Volume 20, Issue 8, Pages (August 2012)
Impact of HDAC inhibitors on dendritic cell functions
Vitamin C: C-ing a New Way to Fight Leukemia
Optimizing autologous cell grafts to improve stem cell gene therapy
Inside This Issue Experimental Hematology
The role of stem cells in aging
Sietske T. Bakker, Emmanuelle Passegué  Experimental Hematology 
Fabian Mohr, Konstanze Döhner, Christian Buske, Vijay P.S. Rawat 
Tumor necrosis factor α in the onset and progression of leukemia
Geneviève Despars, Helen C O'Neill  Experimental Hematology 
p53 Cell Volume 110, Issue 1, Pages 9-12 (July 2002)
Kinase signaling and targeted therapy for primary myelofibrosis
Slugging It out: Fine Tuning the p53-PUMA Death Connection
Stem cell biology and the plasticity polemic
Hematopoietic Stem Cell Heterogeneity Takes Center Stage
Circulating miRNA panel for prediction of acute graft-versus-host disease in lymphoma patients undergoing matched unrelated hematopoietic stem cell transplantation 
Matthew I. Stein, Jiang Zhu, Stephen G. Emerson 
Pediatric leukemia: Moving toward more accurate models
Volume 13, Issue 4, Pages (April 2008)
Dietmar M.W. Zaiss, William C. Gause, Lisa C. Osborne, David Artis 
Cellular Alchemy and the Golden Age of Reprogramming
Stems Cells and the Pathways to Aging and Cancer
The Role of TET2 in Hematologic Neoplasms
Presentation transcript:

Terminal differentiation induction as DNA damage response in hematopoietic stem cells by GADD45A  Susanne Wingert, Michael A. Rieger  Experimental Hematology  Volume 44, Issue 7, Pages 561-566 (July 2016) DOI: 10.1016/j.exphem.2016.04.006 Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions

Experimental Hematology 2016 44, 561-566DOI: (10. 1016/j. exphem. 2016 Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions

Figure 1 DNA damage responses in murine hematopoietic stem and committed progenitor cells. Simplified scheme of the major cell fate decisions and functions in response to DNA damage-causing incidents. Quiescent HSCs employ the error-prone NHEJ pathway as a DNA repair mechanism, whereas activated HSCs and committed progenitors use high-fidelity HR. HSCs are specifically resistant to DNA damage-causing conditions, even at the expense of accumulating mutations. Proposed here as a stem cell-mediated DDR, they terminally differentiate and thereby lose their self-renewal capacity to be eradicated from the system. Committed progenitors arrest primarily in their cell cycle or undergo cell death on DNA damage. Experimental Hematology 2016 44, 561-566DOI: (10.1016/j.exphem.2016.04.006) Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions

Figure 2 Proposed functions of GADD45A in the DDR of adult HSCs. In contrast to several other cellular systems, GADD45A is not involved in mediating cell cycle arrest, and its absence may lead to only mild changes in the survival of adult HSCs. The upregulation of GADD45A robustly induces and accelerates the differentiation process via the MAPK p38 pathway. Loss-of-GADD45A function studies establish the role of GADD45A in mediating DNA repair. Both fate controls may have important tumor-suppressive functions in HSCs. Experimental Hematology 2016 44, 561-566DOI: (10.1016/j.exphem.2016.04.006) Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions