Silent Mutations Make Some Noise

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Silent Mutations Make Some Noise Siyuan Zheng, Hoon Kim, Roel G.W. Verhaak Cell Volume 156, Issue 6, Pages 1129-1131 (March 2014) DOI: 10.1016/j.cell.2014.02.037 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Synonymous Mutations Can Alter Pre-mRNA Splicing (A) A synonymous mutation leads to the gain of an exonic splicing enhancer motif. Consequently, binding of the splicing regulator SRSF1 is enhanced, resulting in the inclusion of an otherwise skipped exon. (B) A synonymous mutation deactivates an exonic splicing silencer motif, thereby abolishing the binding of hnRNP splicing regulators. Cell 2014 156, 1129-1131DOI: (10.1016/j.cell.2014.02.037) Copyright © 2014 Elsevier Inc. Terms and Conditions