Control Subjects MPHD Patients Control Subjects MPHD Patients

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Control Subjects MPHD Patients Control Subjects MPHD Patients Fig.1 Individual peak serum GH concentrations in control subjects and in patients with MPHD for: A, ITT, B, ARG-GHRH; C, ARG-L-Dopa; D, ARG; and E, L-Dopa. Panel F depicts serum IGF-1 concentrations measured at the screening visit in the two groups. The median peak GH or IGF-1 level in each groups denoted with a bar. The upper right box in each stimulation test panel shows the time course of the mean GH response in the two groups. The dashed lines and superscripts indicate diagnostic cut-points that can be employed as follows: a, minimize misclassification of MPHD patients and control subjects; b, 95% sensitivity for GHD; and c, 95% specificity for GHD A. Insulin Tolerance Test B. Arginine-GHRH Peak Serum GH (µg/L) Peak Serum GH (µg/L) __ Median Control Subjects MPHD Patients __ Median Control Subjects MPHD Patients Abbildung mod. nach Biller, 2002

Control Subjects MPHD Patients Control Subjects MPHD Patients Fig.1 Individual peak serum GH concentrations in control subjects and in patients with MPHD for: A, ITT, B, ARG-GHRH; C, ARG-L-Dopa; D, ARG; and E, L-Dopa. Panel F depicts serum IGF-1 concentrations measured at the screening visit in the two groups. The median peak GH or IGF-1 level in each groups denoted with a bar. The upper right box in each stimulation test panel shows the time course of the mean GH response in the two groups. The dashed lines and superscripts indicate diagnostic cut-points that can be employed as follows: a, minimize misclassification of MPHD patients and control subjects; b, 95% sensitivity for GHD; and c, 95% specificity for GHD C. Arginine-L-Dopa D. Arginine Peak Serum GH (µg/L) Peak Serum GH (µg/L) __ __ Median Control Subjects MPHD Patients Median Control Subjects MPHD Patients Abbildung mod. nach Biller, 2002

Control Subjects MPHD Patients Control Subjects MPHD Patients Fig.1 Individual peak serum GH concentrations in control subjects and in patients with MPHD for: A, ITT, B, ARG-GHRH; C, ARG-L-Dopa; D, ARG; and E, L-Dopa. Panel F depicts serum IGF-1 concentrations measured at the screening visit in the two groups. The median peak GH or IGF-1 level in each groups denoted with a bar. The upper right box in each stimulation test panel shows the time course of the mean GH response in the two groups. The dashed lines and superscripts indicate diagnostic cut-points that can be employed as follows: a, minimize misclassification of MPHD patients and control subjects; b, 95% sensitivity for GHD; and c, 95% specificity for GHD E. L-Dopa F. Serum IGF-1 Serum IGF-1 (µg/L) Peak Serum GH (µg/L) __ __ Control Subjects MPHD Patients Median Control Subjects MPHD Patients Median Abbildung mod. nach Biller, 2002

GH Stimulation Test Patients with 0-1 PHD Peak Serum GH (µg/L)‏ Fig.2 Individual peak serum GH responses to each of the stimulation tests in patients with 0-1 PHD. The median for each test is denoted with an arrow Abbildung mod. nach Biller, 2002