Translational Control by the Eukaryotic Ribosome

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Translational Control by the Eukaryotic Ribosome Ivan Topisirovic, Nahum Sonenberg Cell Volume 145, Issue 3, Pages 333-334 (April 2011) DOI: 10.1016/j.cell.2011.04.006 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 The Interface between Development and Translational Control The loss of function of ribosomal protein RPL38 (L38) leads to a selective reduction in Hox mRNA translation. Reduced Hox proteins in the somites (red), which are precursors of vertebrae, leads to skeletal malformations characteristic of the Ts/+ phenotype. Tissue heterogeneity in the expression of ribosomal proteins (depicted in yellow, blue, and green) suggests that the changes in ribosome composition play an important role in the regulation of translation during embryonic development. Cell 2011 145, 333-334DOI: (10.1016/j.cell.2011.04.006) Copyright © 2011 Elsevier Inc. Terms and Conditions