OA phenotypes, rather than disease stage, drive structural progression – identification of structural progressors from 2 phase III randomized clinical.

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Presentation transcript:

OA phenotypes, rather than disease stage, drive structural progression – identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA M.A. Karsdal, A. Bihlet, I. Byrjalsen, P. Alexandersen, C. Ladel, M. Michaels, J.R. Andersen, B.J. Riis, V. Kraus, A.C. Bay-Jensen, C. Christiansen Osteoarthritis and Cartilage Volume 23, Issue 4, Pages 550-558 (April 2015) DOI: 10.1016/j.joca.2014.12.024 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Baseline JSW, pain and function, stratified by KL Grade. A) Mean JSW in osteoarthritic knees graded KL 0–4 in the total cohort (N = 4390), and the two individual trials, CSMC021C2301 (N = 2352) and CSMC021C2302 (N = 2060). B) JSW in the target (N = 2206) vs the contra-lateral contra-lateral knees (N = 2184) C) Mean WOMAC pain (N = 4299) and function (N = 4278) scores in the total cohort. D) Mean total WOMAC pain in the target (N = 2205) and contra-lateral (N = 2094). Error bars are 95% confidence limit of mean. Osteoarthritis and Cartilage 2015 23, 550-558DOI: (10.1016/j.joca.2014.12.024) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Baseline JSW from mixed model analysis showing the JSW (LS means ± 95% CI) according to KL-score and study (A), KL grade and target knee (B), KL-score and gender (C), BMI in quartiles (E), and KL-score and WOMAC pain (D). Totally 4299 knees had complete data and were included in the model. Osteoarthritis and Cartilage 2015 23, 550-558DOI: (10.1016/j.joca.2014.12.024) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 JSN predictors from mixed model analysis showing the JSN at the 2-year endpoint in the placebo group (LS means ± 95% CI) according to baseline KL-score (A), baseline BMI in quartiles (B; Q1 below 25.6 kg/m2; Q2 25.6–28.4 kg/m2, Q3 28.4–31.8 kg/m2, Q4 31.8 kg/m2 or above), and baseline WOMAC pain group (C; Q1a 0–149 mm, Q1b 150–184 mm, Q2 185–231 mm, Q3 232–289 mm, Q4 290–500 mm). Totally 1457 knees in KL 1, 2, an 3 had complete data and were included in the model. Osteoarthritis and Cartilage 2015 23, 550-558DOI: (10.1016/j.joca.2014.12.024) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions