Ahmad Nadeem, MSca, Sunil K

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Presentation transcript:

Increased oxidative stress and altered levels of antioxidants in asthma Ahmad Nadeem, MSca, Sunil K. Chhabra, MDb, Anbrin Masood, MScc, Hanumanthrao G. Raj, PhDa Journal of Allergy and Clinical Immunology Volume 111, Issue 1, Pages 72-78 (January 2003) DOI: 10.1067/mai.2003.17 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Superoxide anion generation in leukocytes expressed as nanomoles of O2− produced per 15 minutes per 2.5 million cells. ***P < .001. Journal of Allergy and Clinical Immunology 2003 111, 72-78DOI: (10.1067/mai.2003.17) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Lipid peroxides and total protein carbonyls in plasma expressed as micromoles of TBARS per liter and nanomoles per milligram of protein, respectively. ***P < .001. Journal of Allergy and Clinical Immunology 2003 111, 72-78DOI: (10.1067/mai.2003.17) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 3 NOx in plasma expressed as micromoles of NOx per liter. ***P < .001. Journal of Allergy and Clinical Immunology 2003 111, 72-78DOI: (10.1067/mai.2003.17) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 4 Total blood glutathione and total protein sulfhydrils in plasma expressed as millimoles per liter. *P < .05; **P < .01. Journal of Allergy and Clinical Immunology 2003 111, 72-78DOI: (10.1067/mai.2003.17) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 5 Red blood cell SOD and catalase activity expressed as units per gram of hemoglobin. **P < .01; ns, P > .05. Journal of Allergy and Clinical Immunology 2003 111, 72-78DOI: (10.1067/mai.2003.17) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 6 GSH-Px activity in red blood cells (RBC) and leukocytes expressed as micromoles of the reduced form of nicotinamide adenine dinucleotide phosphate oxidized per minute per gram of hemoglobin and nanomoles of the reduced form of nicotinamide adenine dinucleotide phosphate oxidized per minute per 0.5 million cells, respectively. *P < .05; ***P < .001. Journal of Allergy and Clinical Immunology 2003 111, 72-78DOI: (10.1067/mai.2003.17) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 7 Ferric reducing antioxidant power in plasma expressed as micromoles per liter. ns, P > .05. Journal of Allergy and Clinical Immunology 2003 111, 72-78DOI: (10.1067/mai.2003.17) Copyright © 2003 Mosby, Inc. Terms and Conditions