Volume 13, Issue 9, Pages (September 2014)

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Volume 13, Issue 9, Pages 893-903 (September 2014) Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies The Lancet Neurology Volume 13, Issue 9, Pages 893-903 (September 2014) DOI: 10.1016/S1474-4422(14)70171-1 Copyright © 2014 International League Against Epilepsy Consortium on Complex Epilepsies. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Manhattan plots for meta-analyses of all epilepsy (A), genetic generalised epilepsy (B), and focal epilepsy (C) The red line shows our threshold of significance set at p=1·66 × 10−8, and the green line shows the suggestive threshold of p=5 × 10−7. Y axis is broken in all graphs. The Lancet Neurology 2014 13, 893-903DOI: (10.1016/S1474-4422(14)70171-1) Copyright © 2014 International League Against Epilepsy Consortium on Complex Epilepsies. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Genomic context of 2q24.3 signal from all-epilepsy analysis Plot created with LocusZoom (version 1.1). Linkage disequilibrium data taken from the 1000 Genomes Project, HG19, March, 2012. The Lancet Neurology 2014 13, 893-903DOI: (10.1016/S1474-4422(14)70171-1) Copyright © 2014 International League Against Epilepsy Consortium on Complex Epilepsies. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Genomic context of 4p15.1 signal from all-epilepsy analysis Plot created with LocusZoom (version 1.1). Linkage disequilibrium data taken from the 1000 Genomes Project, HG19, March 2012. The Lancet Neurology 2014 13, 893-903DOI: (10.1016/S1474-4422(14)70171-1) Copyright © 2014 International League Against Epilepsy Consortium on Complex Epilepsies. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 4 Genomic context of 2p16.1 signal from analysis of genetic generalised epilepsy Plot created with LocusZoom (version 1.1). Linkage disequilibrium data taken from the 1000 Genomes Project, HG19, March 2012. The Lancet Neurology 2014 13, 893-903DOI: (10.1016/S1474-4422(14)70171-1) Copyright © 2014 International League Against Epilepsy Consortium on Complex Epilepsies. Open Access article distributed under the terms of CC BY Terms and Conditions