Amyloid-beta circulates in blood and brain

Slides:



Advertisements
Similar presentations
Immune System.
Advertisements

Defense Against Infectious Disease
The Immune system.
First line of defense (non-specific barriers) : physical and chemical barriers that prevent pathogens from entering (skin, mucus, acids in the stomach,
The body’s defenses. Reading: Ch. 43; Keywords Lines of defense Lymphatic system Inflammation Features of immune system Memory B-cells Primary and secondary.
Blood Type.
Characteristics of the Specific Immune Response It recognizes and targets “specific” pathogens or foreign substances. It has a “memory,” the capacity to.
$100 $200 $300 $400 $500 $100 $200 $300 $400 $500 $100 $200 $300 $400 $500 $100 $200 $300 $400 $500 $100 $200 $300 $400 $500 $100 $200 $300.
Lecture 14/15 – Inflamation & Stress Signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F.
Lymph System Types of Immunity.
Definition of Immunity : It means resistance of the body against foreign body. Foreign body 1.Living body 2.non living body.
VIRUSES Nature’s Robots
Food Allergy & Food Intolerance. Allergy an abnormal reaction of the immune system to foreign (not infectious) material, leading to injury to the body.
THE IMMUNE RESPONSE BIO11 This lesson meets the following DoE Specific Curriculum Outcomes for Biology 11:
Review: Cells of the Immune System From Larsson and Karlsson (2005)
Complement. Innate Immunity Defensive mechanisms include : 1) Innate immunity (Natural or Non specific) 2) Acquired immunity (Adaptive or Specific ) Cell-mediated.
Immune System. Lines of Defense There are 3 lines of defense in the body. The first 2 are nonspecific (they attack everything); the 3rd is specific (it.
Immune System SC.912.L Explain the basic functions of the human immune system, including specific and nonspecific immune response, vaccines, and.
FIGHTING DISEASE SBI 3C: OCTOBER DISEASE:  Pathogen:  A disease causing microorganism  Pathogenic bacteria produce toxins once they enter your.
11.1 Blood Antigens Unit D – Human Systems. Antigens Antigens are protein markers found on the surface of cells. Act like an ID card.
Immune Response and Immunity The Good Fight. Immune Response An immune response is when your body’s B-cells make antibodies against a particular antigen.
The Lymphatic System. Functions of Lymphatic System Drain fluid back into the bloodstream from tissues Filters lymph Filters the blood Fights infections.
اختبارات التعادل المناعي:Neutralization Tests:
31.3 IMMUNE SYSTEM KEY CONCEPT The immune system has many responses to pathogens and foreign cells.
THE WAR INSIDE Immune system vs. disease (pathogens)
Overview of the Immune System
Hypersensitivity reactions
11 – Animal Physiology (HL) 11.1 – Antibody Production and Vaccination
Introduction Basic Immunology
The Lymphatic and Immune Systems
Acquired Immunodeficiency Syndrome
Your body fights off invaders with your...
بهداشت فردي.
Volume 82, Issue 2, Pages (July 2012)
Immunotherapeutic Approaches for Alzheimer’s Disease
Immune System SC.912.L Explain the basic functions of the human immune system, including specific and nonspecific immune response, vaccines,
Many body systems work to produce nonspecific responses.
Trained Immunity: An Ancient Way of Remembering
بنام خداي زيبائيها.
Many body systems work to produce nonspecific responses.
AP Biology Immune Systems Part 2.
Immune Response.
Unit #5C – Clinical Laboratory Testing – Basic Serology/Immunology
Taking Advantage of the Systemic Immune System to Cure Brain Diseases
Complement System Kalpita Mulye.
Protein Misfolding, Amyloid Formation, and Neurodegeneration
Nat. Rev. Rheumatol. doi: /nrrheum
The Immune System Second Edition
Introduction to Lab Ex. 23: Hemagglutination
Brain Check 1. What are the 2 types of host defenses that we have? a. Inherited & Adaptive c. Inherited & Accepted b. Innate & Adaptive d. Innate & Accepted.
Nat. Rev. Cardiol. doi: /nrcardio
Figure 3 LDL autoimmunity in atherosclerosis
Amyloid Cascade into Clarity
Specific Defenses of the Host: The Immune Response
Your body fights off invaders with your...
White Blood Cells Immune System.
Immune System When first exposed to disease, organisms make specific antibodies to mark the foreign invaders so the white blood cells know what to destroy.
Goals & Objectives Identify 2 non-specific immune responses
Myeloid Cells in the Central Nervous System
Phagocytic Leucocytes
Immune System Immune system
Your body fights off invaders with your...
Third Line of Defense Immune Response (Specific Defense)
Figure 3 Blood–brain barrier breakdown promotes neurodegeneration
The Lymphatic System.
Lymphatic & Immune Systems
Cells of the innate and adaptive immune systems.
Immune System ch. 43.
Nat. Rev. Rheumatol. doi: /nrrheum
Animal Defense Mechanisms… Immunity
Presentation transcript:

Figure 2: How the MetO-rich protein immunization helps the clearance of toxic amyloid beta? Amyloid-beta circulates in blood and brain -Forcing the host immune system to produce antibodies against MetO- containing proteins, including: MetO-beta amyloid. Oxidative stress or Aging The Vaccine: a non-toxic MetO-rich protein MetO-beta amyloid Amyloid beta is being oxidized first in its Met residue: yielding a MetO -Amyloid beta Formation of soluble toxic MetO-amyloid-beta aggregates These antibody- MetO-beta amyloid complexes are cleared from the system By macrophages (“packman” –like cells)