Figure 2: How the MetO-rich protein immunization helps the clearance of toxic amyloid beta? Amyloid-beta circulates in blood and brain -Forcing the host immune system to produce antibodies against MetO- containing proteins, including: MetO-beta amyloid. Oxidative stress or Aging The Vaccine: a non-toxic MetO-rich protein MetO-beta amyloid Amyloid beta is being oxidized first in its Met residue: yielding a MetO -Amyloid beta Formation of soluble toxic MetO-amyloid-beta aggregates These antibody- MetO-beta amyloid complexes are cleared from the system By macrophages (“packman” –like cells)