M. Cucchiarini, H. Madry, E.F. Terwilliger

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The survival of motor neuron (SMN) protein: a new factor of the progression of osteoarthritis M. Cucchiarini, H. Madry, E.F. Terwilliger Osteoarthritis and Cartilage Volume 22, Pages S162-S163 (April 2014) DOI: 10.1016/j.joca.2014.02.302 Copyright © 2014 Terms and Conditions

Fig. 1 Histological grading and SMN expression in human normal and osteoarthritic cartilage. All samples were processed for the analysis. (A) safranin O staining of sections from cartilage explants (representative samples). (B) Grading of osteoarthritis severity on safranin O-stained sections from all individual explants (normal donors: n = 13; mild OA: n = 14; moderate OA: n = 22; severe OA: n = 16). (C) SMN-specific immunoreactivity on histological sections from cartilage explants (representative samples). (D) Percentages of SMN-positive cells on immunohistochemical sections from all individual explants. *Statistically significant difference between groups. Osteoarthritis and Cartilage 2014 22, S162-S163DOI: (10.1016/j.joca.2014.02.302) Copyright © 2014 Terms and Conditions

Fig. 2 Correlation and biochemical analysis. (A) All individual values of Fig. 1 (B and D) were combined to evaluate the correlation between the two parameters. (B) Western blotting analysis (1: normal cartilage; 2: mild OA; 3: moderate OA; 4: severe OA; representative samples). (C) SMN concentrations in freshly isolated human normal and osteoarthritic chondrocytes from all the samples. *Statistically significant difference between groups. Osteoarthritis and Cartilage 2014 22, S162-S163DOI: (10.1016/j.joca.2014.02.302) Copyright © 2014 Terms and Conditions