Influence of endogenous estradiol, progesterone, allopregnanolone, and dehydroepiandrosterone sulfate on brain resting state functional connectivity across.

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Presentation transcript:

Influence of endogenous estradiol, progesterone, allopregnanolone, and dehydroepiandrosterone sulfate on brain resting state functional connectivity across the menstrual cycle Sabrina K. Syan, H.B.Sc., Luciano Minuzzi, M.D., Ph.D., Dustin Costescu, M.D., Mara Smith, M.D., Olivia R. Allega, M.Sc., Marg Coote, B.Sc., Geoffrey B.C. Hall, Ph.D., Benicio N. Frey, M.D., M.Sc., Ph.D. Fertility and Sterility Volume 107, Issue 5, Pages 1246-1255.e4 (May 2017) DOI: 10.1016/j.fertnstert.2017.03.021 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Networks of interest identified through ICA: one-sample t test maps of networks of interest (P<.05, FWE-corrected). (A) Anterior DMN; (B) posterior DMN; (C) right FPN; (D) left FPN; (E) MPN; (F) VN; (G) SN; (H) SMN. Fertility and Sterility 2017 107, 1246-1255.e4DOI: (10.1016/j.fertnstert.2017.03.021) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Correlations between hormones and functional coupling in the mid-follicular and late luteal phase: negative correlations between hormones and patterns of coupling are represented in blue, positive correlations represented in red. Intensity of correlations (t values) is represented in the color legend, specific to menstrual phase and hormone. A detailed list of correlation-specific ROIs, Brodmann areas, and R and t values can be found in Supplemental Table 1. Fertility and Sterility 2017 107, 1246-1255.e4DOI: (10.1016/j.fertnstert.2017.03.021) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Statistical profile of menstrual phase–specific hormone correlations with patterns of functional coupling. Fertility and Sterility 2017 107, 1246-1255.e4DOI: (10.1016/j.fertnstert.2017.03.021) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Statistical profile of menstrual phase–specific hormone correlations with patterns of functional coupling. Fertility and Sterility 2017 107, 1246-1255.e4DOI: (10.1016/j.fertnstert.2017.03.021) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Correlation between menstrual–phase specific hormone levels and key regions of networks of interest: hormone levels were correlated with key regions of networks studied in the mid-follicular phase (F) and late luteal phase (L). Fertility and Sterility 2017 107, 1246-1255.e4DOI: (10.1016/j.fertnstert.2017.03.021) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions