Enhanced Anti-Mycobacterial Immunity in Children with Erythema Nodosum and a Positive Tuberculin Skin Test Mark P. Nicol, Beate Kampmann, Patricia Lawrence,

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Enhanced Anti-Mycobacterial Immunity in Children with Erythema Nodosum and a Positive Tuberculin Skin Test Mark P. Nicol, Beate Kampmann, Patricia Lawrence, Kathy Wood, Sandy Pienaar, David Pienaar, Brian Eley, Michael Levin, David Beatty, Suzanne T.B. Anderson Journal of Investigative Dermatology Volume 127, Issue 9, Pages 2152-2157 (September 2007) DOI: 10.1038/sj.jid.5700845 Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Age distribution of children with EN, children with acute PTB and healthy TST+ children. Lines represent median values. Children with TST+ EN fell into two distinct age groups. Journal of Investigative Dermatology 2007 127, 2152-2157DOI: (10.1038/sj.jid.5700845) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Cytokine responses (a: IFNγ, b: TNF, c: IL12p70, d: IL-10) in whole blood by category. Diluted whole blood was stimulated with PPD (for measurement of IFNγ and IL-10), with LPS (TNF measurement) or LPS plus IFNγ (IL-12p70). Cytokines in culture supernatants were measured by ELISA in children with EN, acute PTB or healthy TST+ children. Plots show median values with quartiles. Whiskers show highest and lowest values. Blood from children with EN produced significantly more IFNγ in response to PPD than healthy TST+ children or children with PTB. Journal of Investigative Dermatology 2007 127, 2152-2157DOI: (10.1038/sj.jid.5700845) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 BCG lux GRs by category. Diluted whole blood was incubated with BCG lux for 96hours and the GR calculated using the formula: luminescence at 96hours/luminescence at 0 hour. Children with EN, acute PTB and healthy TST+children. Lines represent median values. Blood from children with EN restricted the growth of BCG lux significantly more than healthy TST+ children or children with PTB. Journal of Investigative Dermatology 2007 127, 2152-2157DOI: (10.1038/sj.jid.5700845) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions