Volume 39, Issue 3, Pages (September 2003)

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Volume 39, Issue 3, Pages 357-364 (September 2003) Regeneration of hepatocyte ‘buds’ in cirrhosis from intrabiliary stem cells Olga Falkowski, Hee Jung An, I.Andreea Ianus, Luis Chiriboga, Herman Yee, A.Brian West, Neil D Theise Journal of Hepatology Volume 39, Issue 3, Pages 357-364 (September 2003) DOI: 10.1016/S0168-8278(03)00309-X

Fig. 1 (A) Intraseptal hepatocyte (ISH) nodule in hepatitis C cirrhosis (H&E, original magnification 10×). (B) Adjacent level as in 1A, immunostained for cytokeratin 19, highlighting the association of a ductular reaction with the ISH nodule. (Immunostained with DAB colorizing agent, Mayer's hematoxylin counter stain, original magnification 10×). (C) ISH loose cluster in primary sclerosing cholangitis cirrhosis (H&E, original magnification 20×). (D) Adjacent level as in 1C, immunostained for cytokeratin 19, highlighting the absence of associated ductular reaction. Note the positive staining bile ducts nearby. (Immunostained with DAB colorizing agent, Mayer's hematoxylin counter stain, original magnification 20×). Journal of Hepatology 2003 39, 357-364DOI: (10.1016/S0168-8278(03)00309-X)

Fig. 2 Cholestatic intraseptal hepatocytes with bile staining, feathery degeneration and Mallory body formation from a patient with primary biliary cirrhosis (H&E, original magnification 20×). Journal of Hepatology 2003 39, 357-364DOI: (10.1016/S0168-8278(03)00309-X)

Fig. 3 Serial, 4 micron sections of hepatitis C cirrhosis. A small intraseptal hepatocyte cluster links directly to an interlobular bile duct as seen in three sequential 4 micron slides (Immunostained with DAB colorizing agent, Mayer's hematoxylin counter stain, original magnification 40×). Journal of Hepatology 2003 39, 357-364DOI: (10.1016/S0168-8278(03)00309-X)

Fig. 4 Serial, 4 micron sections of hepatitis C cirrhosis. A small intraseptal hepatocyte nodule links to an interlobular bile duct via a single intermediate, cytokeratin 19 positive, canal of Hering-like structure, as seen in four sequential 4 micron slides. The complete link can only be appreciated with examination of the serial sections (top of each image). (Immunostained with DAB colorizing agent, Mayer's hematoxylin counter stain, original magnification 20×). Journal of Hepatology 2003 39, 357-364DOI: (10.1016/S0168-8278(03)00309-X)

Fig. 5 Proliferation indices for hepatocytes, cholangiocytes, and ductular reactions in cases of chronic hepatitis C, stages 0 (no fibrosis), 1 (portal fibrosis), 2 (fibrous septa), 3 (transition to cirrhosis), and 4 (cirrhosis). Note that hepatocellular proliferation increases dramatically in even the earliest stages of disease, falling off in cirrhosis, while biliary cells of the ductular reaction and bile ducts begin to significantly increase proliferation only in the latest stages of disease. (CoH, Canal of Hering). Journal of Hepatology 2003 39, 357-364DOI: (10.1016/S0168-8278(03)00309-X)