Figure 1 Increased absolute mean curvature in very premature-born adults. Statistical parametric map of group ... Figure 1 Increased absolute mean curvature.

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Presentation transcript:

Figure 1 Increased absolute mean curvature in very premature-born adults. Statistical parametric map of group ... Figure 1 Increased absolute mean curvature in very premature-born adults. Statistical parametric map of group comparison for AMC between VP/VLBW and full-term (FT) adults. Bihemispheric lateral and medial views are shown. Two-sample t-test, P < 0.05, FWE-corrected, threshold-free cluster enhancement was used. Colour bars indicate P-values for increased AMC in the VP/VLBW group. Warm colours represent lower P-values. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, awz071, https://doi.org/10.1093/brain/awz071 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 2 Associations of increased absolute mean curvature with variables of premature birth. (A) Statistical ... Figure 2 Associations of increased absolute mean curvature with variables of premature birth. (A) Statistical parametric map of negative associations between AMC and gestational age within the VP/VLBW group, controlled for residuals of birth weight and INTI, sex and scanner. (B) Statistical parametric map of negative associations between AMC and birth weight within the VP/VLBW group, controlled for residuals of gestational age and INTI, sex and scanner. (C) Statistical parametric map of positive associations between AMC and INTI within the VP/VLBW , controlled for residuals of gestational age and birth weight, sex and scanner. Bihemispheric lateral and medial views are shown. Multiple regression analyses, P < 0.05, FWE-corrected, threshold-free cluster enhancement was used. Between-group difference in AMC was used as explicit mask. Colour bars indicate P-values for associations between AMC and gestational age (A), birth weight (B), and INTI (C), respectively, in the VP/VLBW group. Warm colours represent lower P-values. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, awz071, https://doi.org/10.1093/brain/awz071 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 3 Linking increased AMC, reduced FS-IQ, and prematurity Figure 3 Linking increased AMC, reduced FS-IQ, and prematurity. (A) Statistical parametric map of negative ... Figure 3 Linking increased AMC, reduced FS-IQ, and prematurity. (A) Statistical parametric map of negative associations between FS-IQ and AMC within the VP/VLBW group. Bihemispheric lateral and medial views are shown. Multiple regression analyses, P < 0.05, FWE-corrected, threshold-free cluster enhancement was used. Between-group difference in AMC were used as explicit mask. Colour bars indicate P-values for negative associations between AMC and FS-IQ in the VP/VLBW group. Warm colours represent lower P-values. Two-way path diagrams are shown to illustrate results of mediation analyses: (B) Scheme of mediation analysis for mean AMC of the group difference cluster of Fig. 1. (C) Scheme of mediation analysis for mean AMC restricted to bilateral PoCC and to bilateral LTC. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, awz071, https://doi.org/10.1093/brain/awz071 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 4 Brain gyrification development mediates the association between prematurity and adult FS-IQ. Three-way path ... Figure 4 Brain gyrification development mediates the association between prematurity and adult FS-IQ. Three-way path diagrams are shown to illustrate results of mediation analyses: (A) ‘Sequential’ mediation analysis comparing the mediating effects of AMC in the PoCC and the LTC between prematurity (=causal variable) and FS-IQ (=outcome variable). Indirect mediating effect of LTC-AMC alone is significant (1.41 ± 0.71; 95% CI: 0.23–3.00). Sequential mediation effect of PoCC-AMC on FS-IQ via LTC-AMC is significant (1.22 ± 0.56; 95% CI: 0.23–2.39). (B) ‘Sequential’ mediation analysis comparing the mediating effects of AMC in the PoCC and the LTC between gestational age (=causal variable) and FS-IQ (=outcome variable). Indirect mediating effect of LTC-AMC alone is significant (0.63 ± 0.27; 95% CI: 0.15–1.20). Sequential mediation effect of PoCC-AMC on FS-IQ via LTC-AMC is significant (0.32 ± 0.17; 95% CI: 0.05–0.70). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, awz071, https://doi.org/10.1093/brain/awz071 The content of this slide may be subject to copyright: please see the slide notes for details.