Biological network analysis of differentially expressed proteins in both pancreatic cancer and chronic pancreatitis using MetaCore mapping tool. Biological.

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Biological network analysis of differentially expressed proteins in both pancreatic cancer and chronic pancreatitis using MetaCore mapping tool. Biological network analysis of differentially expressed proteins in both pancreatic cancer and chronic pancreatitis using MetaCore mapping tool. The network was generated using the shortest path algorithm to map interaction between the proteins. Nodes represent proteins; lines between the nodes indicate direct protein-protein interaction. A small red circle denotes an overexpressed protein, whereas a small blue circle denotes an underexpressed protein. PKC, protein kinase C; PKB, protein kinase B; MHC, major histocompatibility complex; PI3K, phosphoinositide 3-kinase; cat, catalytic; reg, regulatory; PtdIns(3,4,5)P3, phosphatidylinositol 3,4,5-trisphosphate; Erk, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; MEK, MAPK/ERK kinase; MEKK, MEK kinase; IL-1, interleukin-1; IL-1RI, type I IL-1 receptor; A2M, α2-macroglobulin; IRAK, IL-1R-associated kinase; HPRG, histidine-proline-rich-glycoprotein; TABP, truncated actin-binding protein; SITPEC (ECSIT), signaling intermediate in Toll pathway-evolutionarily conserved (evolutionarily conserved signaling intermediate in toll pathways); IP3R2, inositol 1,4,5-trisphosphate receptor type 2; JNK, c-Jun NH2-terminal kinase; SOS, son of sevenless; HPRG, histidine-rich glycoprotein; FCGRT, IgG receptor FcRn large subunit p51. Ru Chen et al. Mol Cell Proteomics 2007;6:1331-1342 © 2007 The American Society for Biochemistry and Molecular Biology