PS202. Propagermanium, a CCR2 Signaling Inhibitor, Suppresses Monocyte Mobilization and Migration in Experimental Aneurysms Naoki Fujimura, Baohui Xu,

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PS202. Propagermanium, a CCR2 Signaling Inhibitor, Suppresses Monocyte Mobilization and Migration in Experimental Aneurysms Naoki Fujimura, Baohui Xu, Haojun Xuan, Jackson Dalman, Yuko Furusho, Hiroki Tanaka, Keith Glover, Martin Rouer, Kohji Aoyama, Sara A. Michie, Ronald L. Dalman Journal of Vascular Surgery Volume 59, Issue 6, Pages 81S-82S (June 2014) DOI: 10.1016/j.jvs.2014.03.183 Copyright © 2014 Terms and Conditions

Fig PG treatment suppresses the formation and progression of experimental AAAs. (A): Mice were treated with PG (50 mg/kg/day) (PG progression) or vehicle for one week prior to PPE infusion and 2 weeks thereafter, and aortic diameters were serially measured via ultrasonography. (B): PPE-infused mice were treated PG (PG regression) or vehicle beginning day 4 following PPE for 10 days. Data are absolute changes in aortic diameters over those on 3 days following PPE infusion. (C, D): Quantification of aortic macrophages (CD68∗ cells) and mural angiogenesis (CD31∗ blood vessels) per aortic cross section (ACS). (E): Absolute numbers of inflammatory monocytes (CD11b∗, Ly-6chigh) peripheral blood (PB), bone marrow (BM) and spleen (Sp) measured via cell suspension immunofluorescence staining and flow cytometric analysis. (F): Effect of PG treatment on in vivo migration of intravenously transferred fluorescence RFP-tagged monocytes into aneurysmal aortae. Migration in PG treatment group is presented as the percentage of monocyte migration in the vehicle group in which the migration was set at 100%. LN: lymph nodes. All data are mean and standard deviation from 5-8 mice in each group. Non-parameteric Mann-Whitney test or two-way ANOVA followed by Newman Keuls post test, ∗P<0.05 and ∗∗P<0.01 compared with vehicle group. Journal of Vascular Surgery 2014 59, 81S-82SDOI: (10.1016/j.jvs.2014.03.183) Copyright © 2014 Terms and Conditions