High serum neopterin and low cytokine values may indicate a non-bacterial etiology for fever of unknown origin in neutropenic patients Per Engervall,

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Presentation transcript:

High serum neopterin and low cytokine values may indicate a non-bacterial etiology for fever of unknown origin in neutropenic patients Per Engervall, Birger Andersson Clinical Microbiology and Infection Volume 4, Issue 9, Pages 491-496 (September 1998) DOI: 10.1111/j.1469-0691.1998.tb00403.x Copyright © 1998 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 Serum neopterin levels (mean ±95% confidence interval) before and during the first 24 h after start of fever in 27 neutropenic fever episodes in patients with hematologic malignancies. *p<0.01 compared with –72 to 0 h before start of fever. Clinical Microbiology and Infection 1998 4, 491-496DOI: (10.1111/j.1469-0691.1998.tb00403.x) Copyright © 1998 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 Serum neopterin values in neutropenic patients at start of fever in relation to blood culture findings. Blood-culture-negative (BCN), (n=11), Gram-negative (Gr–) bacteremia (n=7) and Gram-positive (Gram+) bacteremia (n=9). Box plot diagram showing median values: boxes; 25th and 75th percentile; vertical bars, 10th and 90th percentile; circles, minimum and maximum values. Clinical Microbiology and Infection 1998 4, 491-496DOI: (10.1111/j.1469-0691.1998.tb00403.x) Copyright © 1998 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 3 Serum neopterin and serum TNF-α correlations at start of fever in BCN episodes (filled circles; n = 8; r = –0.73) and bacteremias (unfilled circles; n = 12, r=0.74). Clinical Microbiology and Infection 1998 4, 491-496DOI: (10.1111/j.1469-0691.1998.tb00403.x) Copyright © 1998 European Society of Clinical Infectious Diseases Terms and Conditions