Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region

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Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region P. Paschou, Y. Feng, A.J. Pakstis, W.C. Speed, M.M. DeMille, J.R. Kidd, B. Jaghori, R. Kurlan, D.L. Pauls, P. Sandor, C.L. Barr, K.K. Kidd The American Journal of Human Genetics Volume 75, Issue 4, Pages 545-560 (October 2004) DOI: 10.1086/424389 Copyright © 2004 The American Society of Human Genetics Terms and Conditions

Figure 1 Multipoint linkage analysis (GENEHUNTER) of large pedigrees (Yale sample). A, Analysis of TSO and TSC with initial STRP panel. B, Analysis by use of a fine-mapping STRP panel. The American Journal of Human Genetics 2004 75, 545-560DOI: (10.1086/424389) Copyright © 2004 The American Society of Human Genetics Terms and Conditions

Figure 2 Pairwise LD tests at IRSP53 and TBCD regions (X-axis corresponds to distance in kb; LD values are shown at the midpoint of each interval). A, Tests at IRSP53 are significant for all the populations at P<.006 for the intervals between SNPs 11 and 12, 12 and 13, and 13 and 14. At the interval between SNPs 8 and 9, the test is significant at P<.002 for Chuvash, Russians, Danes, Irish, and European Americans. B, Analysis of the TBCD region. Each point corresponds to adjacent SNP intervals (SNPs 16–17, 17–18, 18–19, 19–20, 20–21, 21–22, 22–23, 23–24, and 24–25). All Δ2 values are associated with P<.001, except for the test for the final interval (SNPs 24–25) for the Chuvash (P=.014). The American Journal of Human Genetics 2004 75, 545-560DOI: (10.1086/424389) Copyright © 2004 The American Society of Human Genetics Terms and Conditions