Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar.

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Presentation transcript:

Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation Filippo Maria Ubaldi, M.D., M.Sc., Antonio Capalbo, Ph.D., Alberto Vaiarelli, M.D., Ph.D., Danilo Cimadomo, M.Sc., Silvia Colamaria, M.D., Carlo Alviggi, M.D., Ph.D., Elisabetta Trabucco, M.D., Roberta Venturella, M.D., Gábor Vajta, Ph.D., Laura Rienzi, M.Sc. Fertility and Sterility Volume 105, Issue 6, Pages 1488-1495.e1 (June 2016) DOI: 10.1016/j.fertnstert.2016.03.002 Copyright © 2016 The Authors Terms and Conditions

Figure 1 (A) Dual stimulation protocol. Five days after the first oocyte retrieval, luteal phase stimulation was performed with an identical protocol (as described in Materials and Methods). Each square represents a day of the cycle. (B) Patient flowchart. (C) Number of patients with at least one euploid blastocyst according to the relative contribution of each stimulation phase. The number of patients who could cumulatively obtain a euploid blastocyst increased from 18 (41.9%) of 43 to 30 (69.8%) of 43 when including the luteal phase-derived blastocysts. Twelve patients (27.9%) had euploid blastocysts exclusively after the luteal phase stimulation. Fertility and Sterility 2016 105, 1488-1495.e1DOI: (10.1016/j.fertnstert.2016.03.002) Copyright © 2016 The Authors Terms and Conditions

Supplemental Figure 1 Graphic representation of the 43 patients included in both follicular and luteal phase stimulation. Each row represents a single patient. Each circle represents a metaphase 2 (MII) oocyte. The black circles represent MII oocytes that did not reach the blastocyst stage after intracytoplasmic sperm injection (ICSI). The red circles represent MII oocytes that developed as aneuploid blastocysts after ICSI. The green circles represent MII oocytes that developed as euploid blastocysts after ICSI. The numbers within circles represent the day of blastocyst development. Fertility and Sterility 2016 105, 1488-1495.e1DOI: (10.1016/j.fertnstert.2016.03.002) Copyright © 2016 The Authors Terms and Conditions