M. R. Doschak, Ph. D. , J. M. LaMothe, Ph. D. , D. M. L. Cooper, B. Sc

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Bisphosphonates reduce bone mineral loss at ligament entheses after joint injury M.R. Doschak, Ph.D., J.M. LaMothe, Ph.D., D.M.L. Cooper, B.Sc., B. Hallgrimsson, Ph.D., D.A. Hanley, M.D., R.C. Bray, M.D., R.F. Zernicke, Ph.D. Osteoarthritis and Cartilage Volume 13, Issue 9, Pages 790-797 (September 2005) DOI: 10.1016/j.joca.2005.04.015 Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 Diagram illustrating isolation of the medial femoral condyle (red dotted line), and the transverse plane of subsequent μCT slices (green plane). The MCL insertion appeared as a cortical depression. Osteoarthritis and Cartilage 2005 13, 790-797DOI: (10.1016/j.joca.2005.04.015) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 Diagram demonstrating the intersects drawn to isolate the MCL insertion, for subsequent areal quantitation and volume determination. For ACLX samples, osteophytes were excluded from the measurements. Osteophyte margins were readily discernible against the compact cortical bone, when viewed on the high resolution CT scans. Osteoarthritis and Cartilage 2005 13, 790-797DOI: (10.1016/j.joca.2005.04.015) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 3 Volume of the MCL insertion. Values are means±SD. ACLX, anterior cruciate ligament transected; rised, risedronate-dosed. Osteoarthritis and Cartilage 2005 13, 790-797DOI: (10.1016/j.joca.2005.04.015) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 4 Two-dimensional μCT images of exemplar medial femoral condyles, illustrating the MCL insertion (arrow) in time zero control, and subsequent bone adaptation in 6 wk ACLX, 14 wk ACLX, and 6 wk ACLX-risedronate-dosed animals. Dashed lines denote sagittal cuts dividing distal medial and lateral condyles (lateral condyle not shown). Osteoarthritis and Cartilage 2005 13, 790-797DOI: (10.1016/j.joca.2005.04.015) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 5 Three-dimensional renderings of two-dimensional μCT images, from exemplar medial femoral condyles, illustrating the MCL-insertion bony depression and bone adaptation in ACLX limbs. Osteoarthritis and Cartilage 2005 13, 790-797DOI: (10.1016/j.joca.2005.04.015) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 6 Histological sections of the MCL insertion, stained with Safranin-O trichrome, illustrating the loss of basophilic-staining mineral at the MCL-bone interface in ACLX limbs. Osteoarthritis and Cartilage 2005 13, 790-797DOI: (10.1016/j.joca.2005.04.015) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 7 The relationship between the volume of bone mineral at the MCL insertion with respect to MCL-complex laxity. Osteoarthritis and Cartilage 2005 13, 790-797DOI: (10.1016/j.joca.2005.04.015) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions