Humanized anti–IFN-γ (HuZAF) in the treatment of psoriasis

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Presentation transcript:

Humanized anti–IFN-γ (HuZAF) in the treatment of psoriasis Jamie L. Harden, PhD, Leanne M. Johnson-Huang, PhD, Maria Francesca Chamian, MD, Edmund Lee, MD, Tillman Pearce, MD, Craig L. Leonardi, MD, Asifa Haider, PhD, Michelle A. Lowes, MD, PhD, James G. Krueger, MD, PhD Journal of Allergy and Clinical Immunology Volume 135, Issue 2, Pages 553-556.e3 (February 2015) DOI: 10.1016/j.jaci.2014.05.046 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Effect of a single dose of HuZAF (10 mg/kg) for treatment of psoriasis. H&E (A) and K16 (B) staining of a responding patient. C, PASI scores for 2 patients. D, Epidermal thickness in baseline nonlesional (NL) and lesional skin (LS), as well as day 29 posttreatment. E, CD3+ T cells quantified by immunohistology. F, Inflammatory gene expression as determined by quantitative RT-PCR. G, Staining of HuZAF using AF2id. All histology images shown at same magnification; bar = 10 μm. Each colored line represents a single patient. H&E, Hematoxylin and eosin. Journal of Allergy and Clinical Immunology 2015 135, 553-556.e3DOI: (10.1016/j.jaci.2014.05.046) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Results of a multiple-dose regimen of HuZAF in the treatment of psoriasis. A, PASI scores in patients receiving 4 HuZAF infusions (arrows indicate the administration of treatment). B and C, Inflammatory gene expression as determined by quantitative RT-PCR, for each patient in nonlesional (NL), lesional (LS), and posttreatment LS skin. Each colored line represents a single patient. Journal of Allergy and Clinical Immunology 2015 135, 553-556.e3DOI: (10.1016/j.jaci.2014.05.046) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Gene expression of single dose HuZAF (10 mg/kg) study. Data from individiual patients are pooled and displayed here. Error bars = SE. Data analyzed using paired t test. ∗P < .05. Journal of Allergy and Clinical Immunology 2015 135, 553-556.e3DOI: (10.1016/j.jaci.2014.05.046) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Gene expression of multi-dose HuZAF trial. Inflammatory gene expression determined in biopsies of basline NL and LS, as well as post-treatment. Data from 10 individual patients (A) and combined data (mean) from all 10 patients (B); error bars = SE. Data analyzed using paired t test. ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001. Journal of Allergy and Clinical Immunology 2015 135, 553-556.e3DOI: (10.1016/j.jaci.2014.05.046) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions