Finding Leishmania: A Deadly Game of Hide-and-Seek

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Finding Leishmania: A Deadly Game of Hide-and-Seek Phillip Scott  Cell Host & Microbe  Volume 6, Issue 1, Pages 3-4 (July 2009) DOI: 10.1016/j.chom.2009.07.002 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 T Cell Interactions with Infected Cells in Leishmanial Lesions Antigen-specific (red) and nonspecific T cells (gray) enter leishmanial lesions from the blood with similar frequency [1], but once in the lesions, behave differently. T cells recognizing Leishmania are found in higher frequency in areas where infected CD11b+, CD11c+ dendritic cells (DCs) are located when compared to nonspecific T cells [2]. Some antigen-specific T cells are in contact with infected DCs, while others only transiently scan the infected cells. Other regions with infected DCs exclude T cells altogether [3]. Cell Host & Microbe 2009 6, 3-4DOI: (10.1016/j.chom.2009.07.002) Copyright © 2009 Elsevier Inc. Terms and Conditions