Validation of bioinformatic screening of a patient cohort.

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Validation of bioinformatic screening of a patient cohort. Validation of bioinformatic screening of a patient cohort. SDE genes from the clinical cohort were compared with the literature-derived gene list. Shown are overlaps between the gene lists expressed as pie charts, with directionality of agreement indicated for genes on the literature-derived list that are upregulated (A) or downregulated (B). Also shown are relative expression data from RSV-infected patients overlaid on the gene network derived from the literature-derived list (C). Upregulated genes are red, downregulated genes are green, genes identified in bioinformatic study but not clinical study are white, shading represents differential expression, and genes on the literature-derived list are indicated by bold outlining. Jacqueline U. McDonald et al. mSystems 2016; doi:10.1128/mSystems.00051-16