Use of routine clinical multimodality imaging in a rabbit model of osteoarthritis – part I  M. Bouchgua, D.M.V., K. Alexander, D.M.V., M.Sc., Dipl. A.C.V.R., M. André d'Anjou, D.M.V., Dipl. A.C.V.R., C.A. Girard, D.M.V., M.Sc., Dipl. A.C.V.P., E. Norman Carmel, D.M.V., G. Beauchamp, Ph.D., H. Richard, S. Laverty, M.V.B., Dipl. A.C.V.S., E.C.V.S.  Osteoarthritis and Cartilage  Volume 17, Issue 2, Pages 188-196 (February 2009) DOI: 10.1016/j.joca.2008.06.017 Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Timelines of the experimental protocol. Sh=sham, SX=surgery, imaging=CR, CT, MRI, euth=euthanasia/macroscopic/histologic evaluation; n=number of rabbits. Osteoarthritis and Cartilage 2009 17, 188-196DOI: (10.1016/j.joca.2008.06.017) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Grade 3 osteophytosis on AP (A) and mediolateral (B) CR views, coronal (C) and axial (D) CT images, coronal PD-fat saturation (E) and sagittal SPGR (F) MRI images. White arrows illustrate osteophytes. Osteoarthritis and Cartilage 2009 17, 188-196DOI: (10.1016/j.joca.2008.06.017) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Grade 0 (A), 1 (B), 2 (C), 3 (D) of BMLs on coronal T2-fat saturation MRI images. White arrows outline BMLs. Osteoarthritis and Cartilage 2009 17, 188-196DOI: (10.1016/j.joca.2008.06.017) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Illustration of the two extreme knee joint effusion scores (grades 0 and 3) on mediolateral CR views [grade 0 (A), grade 3 (B)], axial CT images [grade 0 (C), grade 3(D)], and sagittal SPGR MRI images [grade 0 (E), grade 3 (F)]. White arrows indicate joint effusion. The white line shows the distance from the midpoint in the proximodistal patellar length to the femoral trochlea, which quantitatively represents femoropatellar effusion. FT=femoral trochlea, P=patella. Osteoarthritis and Cartilage 2009 17, 188-196DOI: (10.1016/j.joca.2008.06.017) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Sagittal SPGR MRI image of the knee joint, showing the site where articular cartilage thickness was measured. The solid white line represents the line tangent to the posterior border of the tibial plateau; the dashed white line represents the tangent to the articular cartilage. Osteoarthritis and Cartilage 2009 17, 188-196DOI: (10.1016/j.joca.2008.06.017) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Total joint osteophyte scores on coronal CT examination. Control R=control right, control L=control left, SX=surgery; n=number of joints, *P≤0.05, **P≤0.01. Osteoarthritis and Cartilage 2009 17, 188-196DOI: (10.1016/j.joca.2008.06.017) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 7 Joint effusion score for each joint over time on CT. Control R=control right, control L=control left, SX=surgery; n=number of joints, *P≤0.05, **P≤0.01. Osteoarthritis and Cartilage 2009 17, 188-196DOI: (10.1016/j.joca.2008.06.017) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 8 Total joint gross morphologic (A) and histologic (B) scores following application of India ink for each group. Control L=control left, control R=control right; n=number of joints, **P≤0.01. Osteoarthritis and Cartilage 2009 17, 188-196DOI: (10.1016/j.joca.2008.06.017) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions