Hotspot Mutation of Brahma in Non-Melanoma Skin Cancer Fergal J. Moloney, J Guy Lyons, Vanessa L. Bock, Xiao X. Huang, Matthew J. Bugeja, Gary M. Halliday  Journal of Investigative Dermatology  Volume 129, Issue 4, Pages 1012-1015 (April 2009) DOI: 10.1038/jid.2008.319 Copyright © 2009 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Q203K mutation in the BRM gene. DHPLC chromatograph (a) of PCR-amplified BRM exon 4 from wild-type DNA, mutant DNA generated by site directed mutagenesis, and SCC DNA. The DHPLC heteroduplex traces are generated using proprietary software. The sequence variation is represented by a differently shaped peak when compared with the wild-type profile. Corresponding sequence profiles (b) for the same tumor compared with germline DNA from the same patient show the single-base substitution. Journal of Investigative Dermatology 2009 129, 1012-1015DOI: (10.1038/jid.2008.319) Copyright © 2009 The Society for Investigative Dermatology, Inc Terms and Conditions