Comprehensive Biomarkers for Personalized Treatment in Pulmonary Large Cell Neuroendocrine Carcinoma: A Comparative Analysis With Adenocarcinoma Takashi.

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Comprehensive Biomarkers for Personalized Treatment in Pulmonary Large Cell Neuroendocrine Carcinoma: A Comparative Analysis With Adenocarcinoma Takashi Makino, MD, Tetuo Mikami, MD, PhD, Yoshinobu Hata, MD, PhD, Hajime Otsuka, MD, PhD, Satoshi Koezuka, MD, Kazutoshi Isobe, MD, PhD, Naobumi Tochigi, MD, PhD, Kazutoshi Shibuya, MD, PhD, Sakae Homma, MD, PhD, Akira Iyoda, MD, PhD The Annals of Thoracic Surgery Volume 102, Issue 5, Pages 1694-1701 (November 2016) DOI: 10.1016/j.athoracsur.2016.04.100 Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Immunohistochemical staining of topoisomerase II (Topo2), somatostatin receptor (SSTR), excision repair cross-complementation group 1 (ERCC1) and epidermal growth factor receptor (EGFR)–L858R. (A) Topo2 in large cell neuroendocrine carcinoma (LCNEC) (score 3); (B) SSTR in LCNEC (score 3); (C) ERCC1 in LCNEC (score 3); (D) EGFR-L858R in adenocarcinoma (score 3). The Annals of Thoracic Surgery 2016 102, 1694-1701DOI: (10.1016/j.athoracsur.2016.04.100) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Significant association of topoisomerase II (Topo2), excision repair cross-complementation group 1 (ERCC1), epidermal growth factor receptor (EGFR)–L858R, and somatostatin receptor (SSTR) staining scores between adenocarcinoma (AC) and large cell neuroendocrine carcinoma (LCNEC). Data are presented as box-and-whisker plots; p values were determined using Wilcoxon rank-sum tests. The Annals of Thoracic Surgery 2016 102, 1694-1701DOI: (10.1016/j.athoracsur.2016.04.100) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Five-year overall survival rates in patients with stage I large cell neuroendocrine carcinoma (LCNEC) and adenocarcinoma (AC). The Annals of Thoracic Surgery 2016 102, 1694-1701DOI: (10.1016/j.athoracsur.2016.04.100) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions