Volume 116, Issue 6, Pages (June 1999)

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Volume 116, Issue 6, Pages 1287-1292 (June 1999) Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice Akihiro Asakawa, Akio Inui, Naohiko Ueno, Susumu Makino, Masayuki A. Fujino, Masato Kasuga Gastroenterology Volume 116, Issue 6, Pages 1287-1292 (June 1999) DOI: 10.1016/S0016-5085(99)70491-9 Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Effects of 0.003-3 nmol of urocortin injected IP on (A) cumulative food intake and (B) change in body weight in food-deprived lean mice. Results are expressed as mean ± SE of 10-12 mice in each experiment. *P < 0.05, **P < 0.01 compared with the control group by Bonferroni t test. 2, Saline; urocortin (in nmol): ▩, 0.003; ▨, 0.03; ▩, 0.3; and ■, 3. Gastroenterology 1999 116, 1287-1292DOI: (10.1016/S0016-5085(99)70491-9) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Effects of 3 nmol of urocortin, urocortin OH, CRF, CCK, CRF6-33, and leptin injected IP on (A) cumulative food intake and (B) change in body weight in food-deprived lean mice. Results are expressed as mean ± SE of 10-12 mice in each experiment. *P < 0.05, **P < 0.01 compared with the control group by Bonferroni t test. 2, Saline; 3 nmol of the following: ▩, leptin; ▩, CRF6-33; ▨, CCK-8; ▨, CRF; ▩, urocortin OH; ■, urocortin. Gastroenterology 1999 116, 1287-1292DOI: (10.1016/S0016-5085(99)70491-9) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Effects of 3 nmol of urocortin injected IP on (A) cumulative food intake and (B) change in body weight in food-deprived ob/ob mice. Results are expressed as mean ± SE of 10 mice in each experiment. *P < 0.05, **P < 0.01 compared with the control group by Bonferroni t test. 2, Saline; ■, 3 nmol urocortin. Gastroenterology 1999 116, 1287-1292DOI: (10.1016/S0016-5085(99)70491-9) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 4 (A) Effects of 3 nmol of urocortin, urocortin OH, CRF, and CCK injected IP on gastric emptying rate after 2, 4, and 8 hours after injection in lean mice. (B) Effects of 3 nmol of urocortin injected IP on gastric emptying rate after 2, 4, and 8 hours after injection in ob/ob mice. Results are expressed as mean ± SE of 5 mice in each experiment. *P < 0.05, **P <0.01 compared with the control group by Bonferroni t test. 2, Saline; 3 nmol of the following: ▩, CCK-8; ▨, urocortin OH; ▩, CRF; ■, urocortin. Gastroenterology 1999 116, 1287-1292DOI: (10.1016/S0016-5085(99)70491-9) Copyright © 1999 American Gastroenterological Association Terms and Conditions