Alterations of Gut Microbiome in Rheumatoid Arthritis X. Wu, J. Liu, L. Xiao, A. Lu, G. Zhang  Osteoarthritis and Cartilage  Volume 25, Pages S287-S288 (April 2017) DOI: 10.1016/j.joca.2017.02.484 Copyright © 2017 Terms and Conditions

Figure 1. Lower alpha diversity as well as lower Firmicutes / Bacteroidetes ratio in the gut microbiome of RA patients when compared with the healthy controls. (a) Plot data of four major index representing the alpha diversity of the gut microbiome in RA and Control groups. (b) Heatmap of OUTs at phylum level in RA and Control groups. Note: All data were mean ± s.d. *** p<0.0001 for RA group vs. Control group. ACE: abundance-based coverage estimators. Osteoarthritis and Cartilage 2017 25, S287-S288DOI: (10.1016/j.joca.2017.02.484) Copyright © 2017 Terms and Conditions

Figure 2. Differentially abundant gut microbiome in RA patients Figure 2. Differentially abundant gut microbiome in RA patients. (a) Data of phylogenetic tree analysis to identify differentially abundant taxa. (b) Percentage of 16S reads of major genus of the gut microbiota of RA patients and controls. (c) Quantification of differentially abundant genus of gut microbiome in RA and Control groups. Osteoarthritis and Cartilage 2017 25, S287-S288DOI: (10.1016/j.joca.2017.02.484) Copyright © 2017 Terms and Conditions

Figure 3. Abundance of Roseburia negatively correlated with the clinical parameters of disease activity in RA patients. Upper pannel: Correlation analysis of the 16S reads number of Roseburia and the erythrocyte sedimentation rate (ESR) in RA patients. Lower pannel: Correlation analysis of the 16S reads number of Roseburia and the blood level of rheumatoid factors (IgM) in RA patients. Note: Pearson rank correlation test was performed to determine correlations in the study variables. Osteoarthritis and Cartilage 2017 25, S287-S288DOI: (10.1016/j.joca.2017.02.484) Copyright © 2017 Terms and Conditions