Achalasia in a Patient Undergoing Hematologic Stem Cell Transplant After Exposure to Tacrolimus Sencer Goklemez, Lauren M. Curtis, MD, Alao Hawwa, MD, Alexander Ling, MD, Daniele Avila, CRNP, Theo Heller, MD, Steven Z. Pavletic, MD Mayo Clinic Proceedings: Innovations, Quality & Outcomes Volume 1, Issue 2, Pages 198-201 (September 2017) DOI: 10.1016/j.mayocpiqo.2017.06.004 Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure A, Results of esophagram at day +35 after transplant, with decreased peristalsis and spasm of the lower esophageal sphincter, consistent with the diagnosis of achalasia. B, Esophagram results at day +96 after transplant, with improved tertiary peristalsis soon after changing tacrolimus to cyclosporine for graft-vs-host disease prophylaxis. C, Esophagram results at day +140 after transplant, with improved esophageal motility pattern and minimally delayed emptying of contrast medium. D, Esophagram results at day +180 after transplant, with resolution of achalasia as seen from near-normal peristalsis as well as widely patent lower esophageal sphincter. Mayo Clinic Proceedings: Innovations, Quality & Outcomes 2017 1, 198-201DOI: (10.1016/j.mayocpiqo.2017.06.004) Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions