Losartan pretreatment reduces neurodegeneration and behavioural symptoms in 6- hydroxydopamine induced unilateral rat model of Parkinson's disease Ali.

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Presentation transcript:

Losartan pretreatment reduces neurodegeneration and behavioural symptoms in 6- hydroxydopamine induced unilateral rat model of Parkinson's disease Ali Moradganjeh, Seyed Ali Ziai, Mehrdad Roghani Pathophysiology Volume 20, Issue 4, Pages 243-248 (September 2013) DOI: 10.1016/j.pathophys.2013.10.001 Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Net total apomorphine-induced rotations in different groups (*p<0.05, **p<0.01 in comparison with the 6-OHDA group and ††p<0.01 compared to the sham group). Pathophysiology 2013 20, 243-248DOI: (10.1016/j.pathophys.2013.10.001) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 The mean of rigidity grade in different groups (***p<0.001 in comparison with the 6-OHDA group and †p<0.05 compared to the sham group). Pathophysiology 2013 20, 243-248DOI: (10.1016/j.pathophys.2013.10.001) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 TBARS content in homogenate of midbrain in different groups (*p<0.05 in comparison with the 6-OHDA group and †p<0.05 compared to the sham group). Pathophysiology 2013 20, 243-248DOI: (10.1016/j.pathophys.2013.10.001) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Protein carbonyl content in homogenate of midbrain in different groups (*p<0.05 in comparison with the 6-OHDA group and ††p<0.01 compared to the sham group). Pathophysiology 2013 20, 243-248DOI: (10.1016/j.pathophys.2013.10.001) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 ACE activity in homogenate of midbrain in different groups (*p<0.05 in comparison with the 6-OHDA group). Pathophysiology 2013 20, 243-248DOI: (10.1016/j.pathophys.2013.10.001) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

Fig. 6 Illustrative photomicrographs of typical coronal section through the midbrain showing Nissl-stained neurons in Sham, 6-OHDA, 6-OHDA+captopril and 6-OHDA+losartan groups on the left (lesion) side of SNC. A considerable reduction in the number of the dopaminergic neurons in SNC was observed in the 6-OHDA group but no such marked decrease was noted in the losartan+6-OHDA group in comparison with the sham group. SNC, substantia nigra pars compacta. SNr, substantia nigra pars reticulate. Pathophysiology 2013 20, 243-248DOI: (10.1016/j.pathophys.2013.10.001) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions