Adaptive Clinical Trial Design: An Overview and Potential Applications in Dermatology  Scott A. Elman, James H. Ware, Alice B. Gottlieb, Joseph F. Merola  Journal of Investigative Dermatology  Volume 136, Issue 7, Pages 1325-1329 (July 2016) DOI: 10.1016/j.jid.2016.02.807 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Adaptive seamless phase II/III trial. The phase II trial begins with several drug regimens; interim analyses are performed, with the goal of identifying the regimens that may be most successful for continuation into phase III without the typical lag time. Data may be accrued from phase II into phase III, requiring fewer patients. Adapted by permission from Macmillan Publishers Ltd: Nature Reviews Drug Discovery, Zumla et al., 2013. Journal of Investigative Dermatology 2016 136, 1325-1329DOI: (10.1016/j.jid.2016.02.807) Copyright © 2016 The Authors Terms and Conditions