Change in lung clearance index (LCI) (mean±sd % change lung turnovers compared with baseline) based on modelled a, b) continuous and c, d) isolated pre-capillary.

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Presentation transcript:

Change in lung clearance index (LCI) (mean±sd % change lung turnovers compared with baseline) based on modelled a, b) continuous and c, d) isolated pre-capillary expiratory leaks in healthy children and children with cystic fibrosis (CF). Change in lung clearance index (LCI) (mean±sd % change lung turnovers compared with baseline) based on modelled a, b) continuous and c, d) isolated pre-capillary expiratory leaks in healthy children and children with cystic fibrosis (CF). VT: tidal volume. a) Continuous 20% VT leak. b) Continuous leaks after one-quarter washout. c) Isolated 20% VT leak. d) Isolated leaks after one-quarter washout. Isolated leaks were defined as occurring over two breaths. Nina Lenherr et al. ERJ Open Res 2018;4:00012-2017 ©2018 by European Respiratory Society