Adapted with permission from Tesfaye, S. , Boulton, A. J

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Figure 1 The peripheral and central changes induced by nerve injury or peripheral neuropathy Adapted with permission from Tesfaye, S., Boulton, A. J. & Dickenson, A. H. Mechanisms and management of diabetic painful distal symmetrical polyneuropathy. Diabetes Care 36, 2456–2465 (2013), American Diabetes Association, 2013. Copyright and all rights reserved. Material from this publication has been used with the permission of American Diabetes Association Colloca, L. et al. (2017) Neuropathic pain Nat. Rev. Dis. Primers doi:10.1038/nrdp.2017.2