Volume 116, Issue 2, Pages (February 1999)

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Volume 116, Issue 2, Pages 310-319 (February 1999) Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats Heiko C. Rath, Jack S. Ikeda, Hans Jörg Linde, Jürgen Schölmerich, Kenneth H. Wilson, R.Balfour Sartor Gastroenterology Volume 116, Issue 2, Pages 310-319 (February 1999) DOI: 10.1016/S0016-5085(99)70127-7 Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Surgical procedures to create an SFBL and exclusion of the cecum with a colostomy (EX). Surgical procedures were performed on 2-month-old TG Fischer rats and nonTG littermates. C, cecum; TI, terminal ileum; TC, transverse colon; DC, descending colon. Gastroenterology 1999 116, 310-319DOI: (10.1016/S0016-5085(99)70127-7) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Quantitation of cecal inflammation in HLA-B27/β2 microglobulin TG rats exposed to variable bacterial loads. Blinded gross (2) and histological (▨) evaluations showed significantly increased inflammation in TG rats with SFBL (N = 8) and significantly decreased inflammation in TG EX rats (N = 8) compared with TG SHAM controls (N = 5). There was no difference between TG EX and nonTG SHAM (N = 5). IL-1β protein concentrations (■) in the cecal tissue confirmed decreased inflammation in TG EX vs. TG SHAM, but showed no difference between TG SFBL and TG SHAM. *P < 0.0001 vs. all other groups. §P < 0.002 vs. TG SFBL and P < 0.0001 vs. TG EX and nonTG SHAM. ¶P < 0.007 vs. TG EX and nonTG SHAM. Gastroenterology 1999 116, 310-319DOI: (10.1016/S0016-5085(99)70127-7) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Histological evidence of cecal inflammation in HLA-B27/β2 microglobulin TG rats exposed to variable bacterial loads (original magnification 400×, except D). (A) TG SHAM rat showing diffuse mucosal inflammation and hyperplasia. (B) TG rat with an excluded cecum shows no evidence of mucosal or submucosal inflammation. (C) TG SFBL rat developed mucosal ulceration and submucosal inflammation. (D) TG SFBL under lower magnification (100×) demonstrating extension of submucosal inflammation away from the ulcer. Gastroenterology 1999 116, 310-319DOI: (10.1016/S0016-5085(99)70127-7) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Histological evidence of cecal inflammation in HLA-B27/β2 microglobulin TG rats exposed to variable bacterial loads (original magnification 400×, except D). (A) TG SHAM rat showing diffuse mucosal inflammation and hyperplasia. (B) TG rat with an excluded cecum shows no evidence of mucosal or submucosal inflammation. (C) TG SFBL rat developed mucosal ulceration and submucosal inflammation. (D) TG SFBL under lower magnification (100×) demonstrating extension of submucosal inflammation away from the ulcer. Gastroenterology 1999 116, 310-319DOI: (10.1016/S0016-5085(99)70127-7) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Histological evidence of cecal inflammation in HLA-B27/β2 microglobulin TG rats exposed to variable bacterial loads (original magnification 400×, except D). (A) TG SHAM rat showing diffuse mucosal inflammation and hyperplasia. (B) TG rat with an excluded cecum shows no evidence of mucosal or submucosal inflammation. (C) TG SFBL rat developed mucosal ulceration and submucosal inflammation. (D) TG SFBL under lower magnification (100×) demonstrating extension of submucosal inflammation away from the ulcer. Gastroenterology 1999 116, 310-319DOI: (10.1016/S0016-5085(99)70127-7) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Histological evidence of cecal inflammation in HLA-B27/β2 microglobulin TG rats exposed to variable bacterial loads (original magnification 400×, except D). (A) TG SHAM rat showing diffuse mucosal inflammation and hyperplasia. (B) TG rat with an excluded cecum shows no evidence of mucosal or submucosal inflammation. (C) TG SFBL rat developed mucosal ulceration and submucosal inflammation. (D) TG SFBL under lower magnification (100×) demonstrating extension of submucosal inflammation away from the ulcer. Gastroenterology 1999 116, 310-319DOI: (10.1016/S0016-5085(99)70127-7) Copyright © 1999 American Gastroenterological Association Terms and Conditions