Volume 67, Issue 3, Pages (March 2005)

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Presentation transcript:

Volume 67, Issue 3, Pages 822-828 (March 2005) Reduced renal reserve and increased cardiac output in adult female sheep uninephrectomized as fetuses Karen M. Moritz, Andrew Jefferies, James Wong, E. Marelyn Wintour, Miodrag Dodic Kidney International Volume 67, Issue 3, Pages 822-828 (March 2005) DOI: 10.1111/j.1523-1755.2005.00147.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Mean arterial blood pressure at 4-hour intervals in female adult sheep at 2 years of age that underwent sham surgery(N = 8)(•) or uninephrectomy(N = 7)(o) at 100 days of gestation. Blood pressure was significantly higher in the uninephrectomy animals [two-way analysis of variance (ANOVA)](P < 0.05). Kidney International 2005 67, 822-828DOI: (10.1111/j.1523-1755.2005.00147.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Glomerular filtration rate (GFR) in sham-operated control animals(N = 8)(•) and unilaterally nephrectomized animals(N = 7)(o) during an intravenous infusion of amino acids for 2 hours. Two-way analysis of variance (ANOVA) (P < 0.05). Tukey post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001 between the groups. Kidney International 2005 67, 822-828DOI: (10.1111/j.1523-1755.2005.00147.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Changes in urinary protein excretion in sham operated control animals(N = 8)(•) and unilaterally nephrectomized animals(N = 7)(o) during an intravenous infusion of amino acids. Two-way analysis of variance (ANOVA). P < 0.05 between the groups. Kidney International 2005 67, 822-828DOI: (10.1111/j.1523-1755.2005.00147.x) Copyright © 2005 International Society of Nephrology Terms and Conditions