Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury  Y. Hijazi, C. Bodonian, M. Bolon, F. Salord,

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Presentation transcript:

Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury  Y. Hijazi, C. Bodonian, M. Bolon, F. Salord, R. Boulieu  British Journal of Anaesthesia  Volume 90, Issue 2, Pages 155-160 (February 2003) DOI: 10.1093/bja/aeg028 Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 1 Typical pharmacokinetic profile of ketamine in one intensive care patient. Data were fitted in a two-compartment model. British Journal of Anaesthesia 2003 90, 155-160DOI: (10.1093/bja/aeg028) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 2 Pharmacokinetic profile of ketamine and its metabolites in twelve intensive care patients with brain or spinal cord injury. Data are mean (sd). British Journal of Anaesthesia 2003 90, 155-160DOI: (10.1093/bja/aeg028) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 3 Percentage change in haemodynamic variables during and after ketamine administration in nine intensive care patients with brain and spinal cord injury, as compared with values before drug administration (time 0). SAP, systolic arterial pressure; DAP, diastolic arterial pressure; HR, heart rate. Data are mean (sem). British Journal of Anaesthesia 2003 90, 155-160DOI: (10.1093/bja/aeg028) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

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