In acute lung injury, inhaled nitric oxide improves ventilation-perfusion matching, pulmonary vascular mechanics, and transpulmonary vascular efficiency

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Presentation transcript:

In acute lung injury, inhaled nitric oxide improves ventilation-perfusion matching, pulmonary vascular mechanics, and transpulmonary vascular efficiency Neal D. Hillman, MDb, Jon N. Meliones, MDa, Donald R. Black, MDa, Damian M. Craig, MSb, Ira M. Cheifetz, MDa, Peter K. Smith, MDb The Journal of Thoracic and Cardiovascular Surgery Volume 110, Issue 3, Pages 593-600 (September 1995) DOI: 10.1016/S0022-5223(95)70089-7 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 The effect of inhaled NO on ventilation perfusion matching. NO significantly improved ventilation-perfusion matching, but no dose-response relationship was noted. When NO was discontinued, ventilation-perfusion matching returned to baseline levels. *p < 0.05 versus 0 ppm. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 593-600DOI: (10.1016/S0022-5223(95)70089-7) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 NO decreased PA pressure, which returned to baseline levels on discontinuation of NO. No dose-response relationship was noted. *p < 0.05 versus 0 ppm. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 593-600DOI: (10.1016/S0022-5223(95)70089-7) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 NO significantly improved transpulmonary vascular efficiency (TVE = pulmonary blood flow/total RV power). *p < 0.05 versus 0 ppm. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 593-600DOI: (10.1016/S0022-5223(95)70089-7) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 Inhaled NO resulted in a significant increase in Pao2. When NO was discontinued, Pao2 returned to baseline values. *p < 0.05 versus 0 ppm. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 593-600DOI: (10.1016/S0022-5223(95)70089-7) Copyright © 1995 Mosby, Inc. Terms and Conditions