Modulation of inflammation by chondroitin sulfate

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Modulation of inflammation by chondroitin sulfate M. Vallières, P. du Souich  Osteoarthritis and Cartilage  Volume 18, Pages S1-S6 (June 2010) DOI: 10.1016/j.joca.2010.02.017 Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 In immune cells, bacteria, protozoa, fungi and viruses activate the PRRs by means of PAMPs and/or LPS, and as a consequence, activate the ERK1/2, p38MAPK, and JNK. These kinases stimulate the nuclear translocation of the p65/p50 heterodimer or NF-κB and binding to target gene, followed by the increase of expression of pro- and anti-inflammatory cytokines, NOS2, COX-2, PLA2 and MMPs, factors that will perpetrate the inflammatory reaction and the inflammatory disease. On the other hand, a sterile tissue lesion will release Hsps, Grps, fibrinogen, surfactant protein A and breakdown products of tissue matrix (fibronectin, hyaluronic acid, and heparan sulfate), compounds that will activate PRRs in immune cells and scavenger receptors in cells of any tissue to further activate the nuclear translocation of NF-κB. Osteoarthritis and Cartilage 2010 18, S1-S6DOI: (10.1016/j.joca.2010.02.017) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 CS, by reducing the phosphorylation of ERK1/2 and p38MAPK, diminishes the nuclear translocation of NF-κB triggered by Hsps, Grps, fibronectin (Fn-f) and EMFs, pro-inflammatory cytokines, IL-1β and TNF-α, PAMPs and LPS. As a consequence, CS reduces the expression of pro-inflammatory cytokines, NOS2, COX-2, PLA2 and MMPs, and diminishes the inflammatory reaction. This mechanism of action may explain the effect of CS in diseases with a strong inflammatory component. Solid large arrow indicates solid clinical evidence, solid narrow arrow denotes preliminary clinical evidence, and broken arrow indicates experimental and/or rather preliminary clinical evidence. Osteoarthritis and Cartilage 2010 18, S1-S6DOI: (10.1016/j.joca.2010.02.017) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions