Autophagy Determines the Path on the TRAIL to Death

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Presentation transcript:

Autophagy Determines the Path on the TRAIL to Death Jun-ichi Sakamaki, Kevin M. Ryan Developmental Cell Volume 37, Issue 4, Pages 291-293 (May 2016) DOI: 10.1016/j.devcel.2016.05.010 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Cell Death Switching in MAP3K7 Knockout Cells TRAIL generally induces cell death through apoptosis (top left panel). Loss of MAP3K7 switches cell fate from apoptosis to necroptosis in response to TRAIL (top middle panel). In this context, necrosome components (RIPK1 and RIPK3) are recruited to the autophagy machinery via p62, leading to phosphorylation of MLKL and execution of necroptosis (lower panel). When necroptosis is inhibited by a RIPK3 inhibitor, (RIPK3i, GSK872) or by RIPK3, MLKL, or p62 knockdown, MAP3K7−/− cells undergo apoptosis in response to TRAIL (top right panel). Developmental Cell 2016 37, 291-293DOI: (10.1016/j.devcel.2016.05.010) Copyright © 2016 Elsevier Inc. Terms and Conditions