Figure 1 Physiological functions of leptin and ghrelin

Slides:

Advertisements

Similar presentations

Temperature Regulation, Thirst, and Hunger

Advertisements

Fat Overweight HDL Diabetes Hypertension Depression Caloric value BMI Overeating Insulin Resistance.

Chapter 36 Food Intake and Metabolism Copyright © 2014 Elsevier Inc. All rights reserved.

Genes that regulate appetite. Wisse, BE. and Schwartz, MW. The skinny on neurotrophins. Commentary on: Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones.

Feeding Pathways. Hunger vs. Satiety Neuroscience (Bears, Connors, Paradiso) Controlled by communication between the gut and parasympathetic nervous system.

In the name of God.

Motivation and Work Chapter 12 notes 12-2 (obj 6-7)

Leptin: Food intake, Energy balance, and Endocrine Function By: Dina M, Trabzuni Advisor; Prof. Hamza Abu-Tarboush 698 FSN.

Regulation of food intake and energy storage

Chronic renal disease: A growing problem

Hormones Impacting Food Seeking Behavior

Leptin-melanocortin system of energy balance

Ann Intern Med. 2010;152(2): doi: / Figure Legend:

Leptin Hormone and Appetite Control

Fig. 1 Severe leptin resistance in the ARC of mice after 16 wk on HFD

C. The arcuate neurons shown in part B project to multiple regions of the hypothalamus. The paraventricular nucleus (PVN) is a convergence zone for many.

Figure 2 Pathophysiology of hyperglycaemia in T2DM

Nat. Rev. Endocrinol. doi: /nrendo

Nat. Rev. Endocrinol. doi: /nrendo

Chronic renal disease: A growing problem

Figure 1 The adult neuroendocrine axes

Does Hypothalamic Inflammation Cause Obesity?

Nat. Rev. Endocrinol. doi: /nrendo

Hypothalamic leptin and insulin signals regulate several peripheral functions. Hypothalamic leptin and insulin signals regulate several peripheral functions.

Topic 6.6: Homoeostasis.

Hypertension in obesity: is leptin the culprit?

Michael K. Badman, Jeffrey S. Flier Gastroenterology

Nat. Rev. Endocrinol. doi: /nrendo

From Lesions to Leptin Neuron

Alexander W. Johnson Trends in Neurosciences

Feeding Pathways.

Figure 4 Effects of irisin on glucose homeostasis

The Hunger Genes: Pathways to Obesity

RIPping off GABA Release in Hypothalamic Circuits Causes Obesity

Nat. Rev. Endocrinol. doi: /nrendo

Neural Control of Energy Balance: Translating Circuits to Therapies

Nat. Rev. Endocrinol. doi: /nrendo

Figure 1 Regulation of hepatic glucose metabolism by the gut, brain and liver Figure 1 | Regulation of hepatic glucose metabolism by the gut, brain and.

Volume 7, Issue 5, Pages (May 2008)

Maribel Rios Trends in Neurosciences

Martin G. Myers, Heike Münzberg, Gina M. Leinninger, Rebecca L. Leshan

Volume 116, Issue 2, Pages (January 2004)

Eating behaviour Neural mechanisms.

Take out a sheet of paper for notes. This will be page 31

Obesity and the Regulation of Energy Balance

The hypothalamus Current Biology

Nat. Rev. Endocrinol. doi: /nrendo

Role of hypothalamic neurogenesis in feeding regulation

Volume 18, Issue 1, Pages (July 2013)

Wai W. Cheung, Robert H. Mak Kidney International

Bone: from a reservoir of minerals to a regulator of energy metabolism

AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism Barbara B. Kahn, Thierry Alquier, David Carling,

Two Paths Diverge in the Brain: Melanin-Concentrating Hormone Controls Hepatic and Adipose Metabolism Nicholas Douris, Eleftheria Maratos–Flier Gastroenterology

Co‐expression of Sorcs1 and Sorcs3 in the hypothalamus

Michael K. Badman, Jeffrey S. Flier Gastroenterology

Volume 9, Issue 6, Pages (June 2009)

The Hormonal Control of Food Intake

Leptin's RIGHT Turn to the Brain Stem

Thoughts for Food: Brain Mechanisms and Peripheral Energy Balance

Hypothalamic clocks and rhythms in feeding behaviour

Volume 24, Issue 13, Pages (July 2014)

Copyright © 2016 Elsevier Inc. All rights reserved.

Figure 3 The hypothalamic–pituitary–gonadal axis

L-AP-4 depressed local synaptic glutamate release in the lateral hypothalamus. l-AP-4 depressed local synaptic glutamate release in the lateral hypothalamus.

SIRT1 and other sirtuins in metabolism

Orphan GPCRs and Neuromodulation

Activation of LHAGal neurons increases motivated feeding behavior.

Activation of LHAGABA neurons increases motivated feeding and chow intake. Activation of LHAGABA neurons increases motivated feeding and chow intake. A,

Of Mice and MEN Stephen R.J Salton, Seung Hahm, Tooru M Mizuno Neuron

Presentation transcript:

Figure 1 Physiological functions of leptin and ghrelin Figure 1 | Physiological functions of leptin and ghrelin. Leptin and ghrelin are secreted from adipose tissue and from the stomach, respectively, enter the circulation and affect a wide range of physiological processes. In addition to direct peripheral targets, these hormones exert their actions in different regions of the brain, including several nuclei of the hypothalamus that are important for energy homeostasis, where both the 'long' form of the leptin receptor (LepRb) and the ghrelin receptor growth hormone secretagogue receptor (GHSR) are broadly expressed. The actions of the two hormones on their receptors regulate food intake and body weight, sympathetic nervous system tone and neuroendocrine responses, which in turn regulate physiological function of peripheral organs to coordinate homeostasis. 3v, third ventricle; ARC, arcuate nucleus of the hypothalamus; DMH, dorsomedial nucleus of the hypothalamus; LHA, lateral hypothalamic area; PVH, paraventricular nucleus of the hypothalamus; VMH, ventromedial nucleus of the hypothalamus. Cui, H. et al. (2017) The cellular and molecular bases of leptin and ghrelin resistance in obesity Nat. Rev. Endocrinol. doi:10.1038/nrendo.2016.222